Efficacy and Tolerability of Quinacrine Monotherapy and Albendazole Plus Chloroquine Combination Therapy in Nitroimidazole-Refractory Giardiasis: A TropNet Study.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Andreas NeumayrEmmanuel Bottieau

Abstract

Giardiasis failing nitroimidazole first-line treatment is an emerging problem in returning European travelers. We present data on the efficacy and tolerability of 2 second-line treatment regimens. This prospective, open-label, multicenter study assessed the efficacy and tolerability of quinacrine monotherapy (100 mg 3 times per day for 5 days) and albendazole plus chloroquine combination therapy (400 mg twice daily plus 155 mg twice daily for 5 days) in nitroimidazole-refractory giardiasis. The defined end points were the clinical outcome, assessed at week 5 after treatment and the parasitological outcome, assessed using microscopy of 2 stool samples, ≥2 to ≤5 weeks after treatment. A total of 106 patients were included in the study. Quinacrine achieved clinical and parasitological cure in 81% (59/73) and 100% (56/56), respectively. Albendazole plus chloroquine achieved clinical and parasitological cure in 36% (12/33) and 48% (12/25), respectively. All patients (9/9) who clinically and parasitologically failed albendazole plus chloroquine treatment and opted for retreatment with quinacrine achieved clinical cure. Mild to moderate treatment-related adverse events were reported by 45% and 30% of patients treated with quinacrine a...Continue Reading

References

Aug 1, 1978·Australian and New Zealand Journal of Medicine·V M DuncombeR L Crouch
Jul 1, 1990·International Journal for Parasitology·J A UpcroftP F Boreham
Mar 1, 1968·The American Journal of Psychiatry·D A Rockwell
Jul 1, 1995·Clinical Microbiology Reviews·M Khaw, C B Panosian
Jan 9, 2001·Clinical Microbiology Reviews·T B Gardner, D R Hill
Jun 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T E NashT A Moore
Mar 26, 2003·The Journal of Antimicrobial Chemotherapy·Agostinho CruzMiguel Cabral
Jul 2, 2003·Annals of Tropical Medicine and Parasitology·A A EscobedoP Almirall
Feb 1, 1964·JAMA : the Journal of the American Medical Association·O L SAPP
Jan 9, 2010·Trends in Parasitology·Lucy J RobertsonNina Langeland
May 21, 2010·PLoS Neglected Tropical Diseases·Shahram Solaymani-MohammadiSteven M Singer
Dec 12, 2012·Travel Medicine and Infectious Disease·Jose Muñoz GutiérrezJoaquim Gascon
Aug 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A Requena-MéndezJ Muñoz
Oct 2, 2014·Emerging Infectious Diseases·Eyal MeltzerEli Schwartz
May 16, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L E B NabarroP L Chiodini
Nov 5, 2016·Current Opinion in Microbiology·Elin EinarssonStaffan G Svärd
Apr 30, 2017·The Journal of Infectious Diseases·Ana Requena-MéndezJosé Muñoz
Jun 19, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E R CarterP L Chiodini
Oct 3, 2018·Current Topics in Medicinal Chemistry·V VivancosM Gonzalez-Alvarez
Jan 7, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Roberto CañeteJohan Ursing
Aug 11, 2020·Current Opinion in Infectious Diseases·Kristine Mørch, Kurt Hanevik

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Infectious Diseases
Karin A YdstenHilmir Asgeirsson
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
E R CarterP L Chiodini
Journal of Travel Medicine
M S Wolfe, R P Handler
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
L E B NabarroP L Chiodini
© 2021 Meta ULC. All rights reserved