Efficacy and tolerability of sertaconazole nitrate 2% cream vs. miconazole in patients with cutaneous dermatophytosis

Mycoses
A SharmaV Baliga

Abstract

Sertaconazole is a new antifungal agent. To compare the efficacy and tolerability of sertaconazole and miconazole cream in cutaneous dermatophytosis, this prospective, randomized, multicentric comparative, phase 4 study was undertaken in 260 patients with cutaneous dermatophytosis after approvals from Institutional Ethics Committees. Patients were assigned to sertaconazole cream (2%) or miconazole cream (2%) topically twice daily for 2 weeks after obtaining informed consent. Efficacy variables included changes in mean scores of erythema, pruritus, desquamation, erythema/itching, burning/weeping, scaling/pustule and overall global assessment. Safety and tolerability were also assessed. A total of 122 patients in the sertaconazole group and 128 in the miconazole group completed the study with 10 drop-outs. There was a significant decrease (P < 0.05) in mean symptom scores and total scores from the first week onwards, sustained till 2 weeks and statistically significant (P < 0.05) in favour of sertaconazole. Moreover, 62.3% patients had complete clinical cure in the sertaconazole group (P < 0.05) compared with 44.6% in miconazole users. Both drugs were well tolerated and five patients in the sertaconazole group and nine in the mic...Continue Reading

References

Dec 19, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J TorresF Camps
Jul 11, 2006·Diagnostic Microbiology and Infectious Disease·Michael A Pfaller, Deanna A Sutton
Jul 27, 2006·Archives of Dermatological Research·Frank LiebelMichael D Southall

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Citations

Apr 3, 2013·Mycopathologia·Alexandro BonifazRosa María Ponce-Olivera
May 20, 2016·Mycopathologia·Alexandro BonifazPonce-Olivera Rosa María
Aug 5, 2014·The Cochrane Database of Systematic Reviews·Magdy El-GoharyPaul Little

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