Efficacy and tolerability of split-dose PEG compared with split-dose aqueous sodium phosphate for outpatient colonoscopy: a randomized, controlled trial.

Digestive Diseases and Sciences
Eun Hee SeoYoung Soo Moon

Abstract

Adequate bowel cleansing is essential for a high-quality, effective, and safe colonoscopy. The aims of this study were to compare the efficacy and tolerability of split-dose polyethylene glycol with aqueous sodium phosphate for outpatients who underwent scheduled colonoscopy. In this prospective trial, 207 outpatients (aged between 18 and 65 years, with normal renal function, at low risk for renal damage) were randomized to receive split-dose preparation of PEG (2 L/2 L) (N = 103) or NaP (45 mL/45 mL, 12 h apart) (N = 104) without strict diet restriction the day before colonoscopy. The bowel cleansing efficacy of preparations was rated according to the Ottawa scale and the patient tolerability was assessed using a patient questionnaire. There was no significant difference between the two groups for the mean total score using the Ottawa bowel preparation scale (P = 0.181). Significantly greater residual colonic fluid was observed in the split-dose PEG group (1.24 ± 0.49) than in the NaP group (1.04 ± 0.53) (P = 0.007). Patient compliance, preference, and acceptance of a two preparation regimen were similar with no significant differences (P = 0.095, P = 0.280 and P = 0.408, respectively). The overall incidence of adverse events ...Continue Reading

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Citations

Aug 13, 2013·Gastroenterology Clinics of North America·Ala I Sharara, Rachel R Abou Mrad
Sep 4, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brintha K EnestvedtM Brian Fennerty
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Oct 8, 2014·The American Journal of Gastroenterology
Jan 18, 2022·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Ankie ReumkensAd A M Masclee

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT01229800

Software Mentioned

SAS

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