Efficacy and tolerability of treatment with lacosamide: Postmarketing experience from the Middle East region

Epilepsy & Behavior : E&B
Maher ArabiAhmad Beydoun

Abstract

Lacosamide (LCM) was recently introduced in the Middle East. The aim of this study was to evaluate the safety, tolerability, and efficacy of LCM in patients with focal onset seizures and determine if our results are comparable with those derived from Western countries. This is a retrospective analysis from two medical centers on consecutive patients diagnosed as having focal onset seizures and treated with add-on LCM. The primary efficacy variables were the 50% responder and seizure-free rates, and the secondary outcome variables included the percentages of patients who achieved seizure remission during the last 6-month follow-up period and the percentages of discontinuation due to lack of efficacy or tolerability. One hundred four patients with a mean age of 30.9 years and experiencing a mean of 9.4 seizures per month during baseline were included. The 50% responder rates were 69% and 70% at 6- and 24-month follow-ups, respectively. Patients concomitantly treated with a sodium channel blocker were less likely to achieve seizure remission during the last 6-month follow-up period while the early introduction of LCM resulted in a significantly higher likelihood of achieving such a remission. Eighty-eight percent of patients were ...Continue Reading

Citations

Jan 9, 2020·Expert Opinion on Drug Safety·Jiyuan LiXuefeng Wang
May 19, 2020·Seizure : the Journal of the British Epilepsy Association·Ghassan HmaimessWassim Nasreddine

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