PMID: 8607723Feb 26, 1996Paper

Efficacy and tolerance of antihypertensive treatment in men and women with stage 1 diastolic hypertension. Results of the Treatment of Mild Hypertension Study

Archives of Internal Medicine
C LewisP J Elmer

Abstract

To explore the sex-specific benefits and risks of treatment of stage 1 diastolic hypertension. Participants were African-American and white hypertensive men (n = 557) and women (n = 345) (age range, 45 to 69 years) with a diastolic blood pressure less than 100 mm Hg. Participants were randomized to treatment with placebo, chlorthalidone (15 mg/d), acebutolol hydrochloride (400 mg/d), doxazosin mesylate (2 mg/d), amlodipine besylate (5 mg/d), or enalapril maleate (5 mg/d); all were given nutritional-hygienic intervention. After 4 years, women who were randomized to lifestyle intervention only were less likely to be receiving step 1 therapy alone (placebo) than men who were randomized to placebo therapy (46% vs 66%, respectively, P < .01). There were significantly greater decreases in the mean systolic blood pressure in both men and women who were assigned to treatment with active drugs compared with those participants who were receiving placebo therapy; differences among treatments with active drugs were similar between men and women. Men experienced larger falls in their total and low-density lipoprotein cholesterol and triglyceride levels regardless of the treatment assignment than did women; however, there were no significant...Continue Reading

Associated Clinical Trials

Citations

Jun 12, 2013·Current Hypertension Reports·Michael DoumasPeter Kokkinos
Dec 2, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Eduardo Pimenta
Dec 14, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Niels Engberding, Nanette K Wenger
Dec 20, 2012·Therapeutic Advances in Chronic Disease·Helga GudmundsdottirIngrid Os
May 22, 2010·Indian Journal of Pharmaceutical Sciences·A HussainK K Pillai
Mar 15, 2003·Clinical Therapeutics·Cindy B LevineVeronica Ludensky
Aug 28, 2013·Advances in Chronic Kidney Disease·Phyllis August
Feb 24, 1998·Mayo Clinic Proceedings·S N Hayes, S J Taler
Mar 10, 2005·The Medical Clinics of North America·Daisy ReyesPaul L Kimmel

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