PMID: 8471820Apr 1, 1993Paper

Efficacy and tolerance of recombinant tissue-type plasminogen activator in patients with thrombotic or embolic occlusions of leg-arteries

The Clinical Investigator
F A SpengelH Stiegler

Abstract

The efficacy and safety of recombinant tissue-type plasminogen activator (rt-PA) was evaluated in 46 patients with thromboembolic arterial occlusions in leg arteries. rt-PA was given over 1-4 h with a maximum dose of 18 mg. The effect of rt-PA treatment was determined as patency of the occluded arteries in 44 different patients 14 days after treatment. In 41 patients at least one artery was recanalized (93%) by rt-PA, and in almost half of these patients (48%) no residual stenosis were detected after the lytic treatment. A slight residual stenosis was detected in 29% of the patients and a severe residual stenosis in 21%. An additional treatment with percutaneous transluminal angioplasty was performed in 23 of the 44 patients and successful in 21 (91%). In 8 patients an addition catheter-embolectomy was performed. No difference in patency rate was detected between patients with thrombotic and those with embolic occlusions. The age of the occlusion influenced the patency rate; occlusions under the age of 5 weeks showed a patency rate of 96% compared to 82% in older occlusions. The length of the occlusion did not have any influence on the outcome of the rt-PA treatment. From the results of this open study we conclude that a dose o...Continue Reading

Citations

Aug 10, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Kenneth Ouriel, Krishna Kandarpa
Dec 23, 2011·Annals of Vascular Surgery·Christian Ochoa, Fred A Weaver
Apr 5, 2001·Journal of Vascular and Interventional Radiology : JVIR·J L SwischukT M Brady
Apr 29, 2000·Journal of Vascular and Interventional Radiology : JVIR·K Valji

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