Efficacy calculation in randomized trials: global or local measures?

Health & Place
Michael EmchJ D Clemens

Abstract

This study tests whether the effect of a vaccine trial varies in space and why. Analytical z-score maps identify unusually high- and low-efficacy values in a trial area. Relationships between neighborhood efficacy and ecological variables are measured to explain why efficacy varies in space. Efficacy was found to vary regardless of neighborhood size and the variation is related to several ecological determinants. Local efficacy measures can help public health practitioners make better decisions about when and where to vaccinate populations. The concepts offered in this study are pertinent for any health intervention trial, not just vaccines.

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Citations

Jan 24, 2012·BMC Research Notes·Antti TanskanenUNKNOWN ARIVAC Consortium
Apr 6, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T Barbosa, M Barral-Netto
Jan 13, 2009·Social Science & Medicine·Michael EmchMohammad Yunus
May 6, 2015·Epidemiology and Infection·D L ChaoM E Halloran
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Elisabeth Dowling RootEric A F Simões
Mar 18, 2011·The Cochrane Database of Systematic Reviews·David SinclairPatricia M Graves
Aug 10, 2021·Current Epidemiology Reports·Griffin J BellJeffrey A Bailey

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