Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials.

The Lancet. Respiratory Medicine
Saad B OmerBMGF Supported Maternal Influenza Immunization Trials Investigators Group

Abstract

Maternal influenza immunisation can reduce morbidity and mortality associated with influenza infection in pregnant women and young infants. We aimed to determine the vaccine efficacy of maternal influenza immunisation against maternal and infant PCR-confirmed influenza, duration of protection, and the effect of gestational age at vaccination on vaccine efficacy, birth outcomes, and infant growth up to 6 months of age. We did a pooled analysis of three randomised controlled trials done in Nepal (2011-2014), Mali (2011-2014), and South Africa (2011-2013). Pregnant women, gestational age 17-34 weeks in Nepal, 28 weeks or more in Mali, and 20-36 weeks in South Africa, were enrolled. Women were randomly assigned 1:1 to a study group, in which they received trivalent inactivated influenza vaccine (IIV) in all three trials, or a control group, in which they received saline placebo in Nepal and South Africa or quadrivalent meningococcal conjugate vaccine in Mali. Enrolment at all sites was complete by April 24, 2013. Infants and women were assessed for respiratory illness, and samples from those that met the case definition were tested for influenza by PCR testing. Growth measurements, including length and weight, were obtained at birt...Continue Reading

Citations

Jan 3, 2021·NeoReviews·Bahaa Abu-Raya, Kirsten Maertens
Feb 26, 2021·Journal of Perinatal Medicine·Sebastian HäuslerSara Fill Malfertheiner
May 4, 2021·Influenza and Other Respiratory Viruses·Janna-Maija MattilaTerho Heikkinen
Jun 9, 2021·JAMA : the Journal of the American Medical Association·Eduardo Azziz-BaumgartnerManish Patel
Nov 5, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Nicola Vousden, Marian Knight

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