Efficacy Endpoints Conference on Acute Rejection in Kidney Transplantation: review of the conference questionnaire

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
D Cantarovich, J P Soulillou

Abstract

Basic differences in the diagnosis and management of acute rejection in renal transplant can be found between centers. A questionnaire was developed to ascertain the profile of these variables. Sixteen fundamental questions were presented to the program directors of 17 transplant groups from around the world. The questions were brief and designed to identify clinical practice and behaviors related to the definition of acute and steroid-resistant rejection, successful response to therapy, use of histological diagnosis, estimated frequency of rejection, and frequency of mild, moderate, or severe acute rejections. Clinicians were presented with case studies and asked to respond to specific questions regarding the rejection management described in these cases to determine similarities in management practices. Results indicated that clinicians relied on clinical symptoms only rarely. Biopsy findings were used by 53% of clinicians, and 94% of clinicians indicated that rejection was suspected if creatinine increased. Successful response was defined as a return to prerejection creatinine level by 77% of clinicians and that steroid-resistant rejection is evident by 5 days. Biopsy was used by 80% of centers to diagnose first acute reject...Continue Reading

Citations

Feb 18, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido FillerAjay P Sharma
Jul 15, 2015·Expert Opinion on Pharmacotherapy·Jamal BamoulidKlemens Budde
Mar 22, 2014·Pediatric Transplantation·Guido FillerShih-Han Susan Huang
Aug 3, 2016·Transplant Immunology·Niels V RekersMichael Eikmans
Aug 15, 2000·American Journal of Obstetrics and Gynecology·L EngineerA R Ahmed
Feb 27, 2018·Canadian Journal of Kidney Health and Disease·Julie LeblancHéloïse Cardinal

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