Efficacy evaluation of personalized coaptation in neurotization for motor deficit after peripheral nerve injury: A systematic review and meta-analysis.

Brain and Behavior
TengDa QianLiXin Li

Abstract

Peripheral neurotization, recently as a promising approach, has taken effect in recovering motor function after damage to a peripheral nerve root. Neural anastomosis comprised of nerve conduit and neurorrhaphy participates in the nerve reconstruction. Current literature lacks evidence supporting an individualized coaptation for rescue of locomotor loss in rat subjects with paraplegia secondary to peripheral nerve injury (PNI). This meta-analysis intends to qualify the specificity of gap-specific coaptation in treating a paralyzed limb following PNI. We used a highly sensitive search strategy to identify all published studies in multiple databases up to 1 May 2019. All identified trials were systematically evaluated using specific inclusion and exclusion criteria. Cochrane methodology was also applied to the results of this study. Twelve studies, including 349 rat subjects, met eligibility criteria. For a medium nerve defect (0.5-3.0 cm), nerve conduit was more likely than neurorrhaphy to precipitate axon regeneration and improve motor outcome of the hemiplegic limb (OR = 3.61, 95% CI = 1.80, 7.26, p < .0003) at 3-month follow-up, whereas neurorrhaphy might take its place in promoting limb motor function in a small nerve gap (<0...Continue Reading

References

Mar 17, 2016·Neural Regeneration Research·Bin-Bin LiShi-Pu Li
Aug 2, 2017·Revista española de cirugía ortopédica y traumatología·B García-MedranoM A Martín Ferrero
Oct 27, 2017·Clinical Neurology and Neurosurgery·Mohammadreza Emamhadi, Sasan Andalib
Nov 5, 2017·Stroke; a Journal of Cerebral Circulation·Christian HerwehThorsten Steiner
Feb 10, 2018·Journal of Neurosurgery. Spine·Xuan YeWen-Dong Xu
Apr 19, 2018·Neurosurgery·John Paul G KolcunMichael Y Wang
Apr 28, 2018·Journal of Tissue Engineering and Regenerative Medicine·Jacqueline J GreeneClaus-Peter Richter
Oct 4, 2018·The Journal of Surgical Research·Masoud YavariAbdolreza Rouientan
Jan 3, 2019·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Konstantin FrankThilo L Schenck
Mar 2, 2019·Neuron·Yuanquan SongYuh Nung Jan
Apr 6, 2019·Journal of Neurosurgery. Spine·Johannes A MayerOskar C Aszmann

❮ Previous
Next ❯

Software Mentioned

Review Manager
Cochrane
SAS
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Baoguo JiangBailin Jiang
World Journal of Orthopedics
Marios G Lykissas
Annals of Plastic Surgery
Samer Bassilios HabreP Konofaos
© 2021 Meta ULC. All rights reserved