Efficacy in patients with dry eye after treatment with a new lubricant eye drop formulation

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
William F DavittAnna Martin

Abstract

The effective management of dry eye must include a clinically meaningful reduction in ocular staining. Evaluations of corneal and conjunctival staining and other ocular symptoms of dry eye were conducted for a new formulation of polyethylene glycol 400/propylene glycol-based lubricant eye drops containing hydroxypropyl guar as a gelling agent (Test Product) in comparison to Optive Lubricant Eye Drops (Control Product) in adult patients with dry eye. One hundred thirteen patients, 18 years of age and older, with dry eye were enrolled in a prospective, double-masked, multisite, parallel-group study. After a 2-week run-in period during which patients administered aqueous saline eye drops 4 times daily (QID) in each eye, patients were randomized (1:1) to receive either Test Product or Control Product to be administered QID for 6 weeks. Efficacy and safety were evaluated by corneal and conjunctival staining scores, tear film breakup time, assessments of ocular symptoms, ocular surface disease index (OSDI) scores, dry eye treatment satisfaction, visual function-14 questionnaires, and adverse events. The intent-to-treat data set included 105 patients randomized to Test Product (n = 52) or Control Product (n = 53). Patients primarily w...Continue Reading

References

May 1, 1994·Archives of Ophthalmology·E P SteinbergA M Damiano
Dec 24, 1997·American Journal of Ophthalmology·O D ScheinS West
Jul 1, 1999·Archives of Internal Medicine·O D ScheinS West
May 18, 2000·Archives of Ophthalmology·R M SchiffmanB L Reis
Sep 12, 2000·Archives of Ophthalmology·S E MossB E Klein
May 30, 2003·Eye & Contact Lens·Gary N Foulks
Jul 31, 2003·American Journal of Ophthalmology·Debra A SchaumbergM Reza Dana
Jan 6, 2004·Current Eye Research·Mike T ChristensenJerry M Stein
Jul 3, 2004·Current Opinion in Ophthalmology·Henry D Perry, Eric D Donnenfeld
Feb 14, 2006·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Paul GiffordJudith Morris

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Citations

Jan 30, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Wanachat ChaiyasanWaree Tiyaboonchai
Jul 14, 2011·Clinical Ophthalmology·Umberto Benelli
Dec 14, 2011·Ophthalmology·Yoshihiro InamotoUNKNOWN Chronic GVHD Consortium
Jul 5, 2013·Expert Opinion on Pharmacotherapy·Michael NyeLeonard Bielory
Mar 16, 2017·Vestnik oftalmologii·V V Brzhesky, S Yu Golubev
Feb 26, 2016·The Cochrane Database of Systematic Reviews·Andrew D PuckerJason J Nichols
May 31, 2019·Eye & Contact Lens·Noor Aniah Azmi, Mae-Lynn Catherine Bastion
Feb 21, 2014·Eye & Contact Lens·Marguerite McDonaldJami R Kern
Nov 7, 2020·Eye & Contact Lens·Chandra V MicklesMelissa Barnett
Jun 18, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Renee GarofaloHoward Ketelson

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