Efficacy of 1,000 mg effervescent acetylsalicylic acid and sumatriptan in treating associated migraine symptoms

European Neurology
H DienerM Voelker

Abstract

Recently a new effervescent acetylsalicylic acid (ASA) tablet with high buffering capacity has been developed. In this double-blind, 3-arm, multicenter, parallel-group study, 433 patients were treated either with 1,000 mg effervescent ASA or 50 mg encapsulated sumatriptan or placebo. The primary endpoint was the percentage of patients with complete remission of the 3 accompanying symptoms nausea, photophobia and phonophobia within 2 h after intake of the study drug. 43.8% of patients treated with ASA, 43.7% of patients treated with sumatriptan and 30.9% of patients treated with placebo showed complete remission of all 3 accompanying symptoms (p < 0.05 for ASA and sumatriptan vs. placebo). Both active treatments were superior to placebo regarding the individual symptoms photophobia and phonophobia, but not for nausea. The percentage of patients with reduction in headache severity from moderate or severe to mild or no pain (secondary objective) was 49.3% for ASA, 48.8% for sumatriptan and 32.9% for placebo. All active treatments were superior to placebo (p < 0.05). 25.3, 24.4 and 14.5% of patients treated with ASA, sumatriptan or placebo were pain free at 2 h. Drug-related adverse events were reported in 3.9, 4.7 and 6.7% of pati...Continue Reading

References

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Citations

Jul 5, 2005·Der Internist·H-C Diener, V Limmroth
Jan 31, 2012·Inflammopharmacology·S A Cooper, M Voelker
Sep 12, 2008·Internal and Emergency Medicine·Paolo MartellettiUNKNOWN Working Group for Specialist Education, WHO's Global Campaign to Reduce the Burden of Headache Worldwide (Lifting The Burden
Aug 28, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S EversUNKNOWN European Federation of Neurological Societies
Sep 10, 2014·The Journal of Headache and Pain·Inga L Kröger, Arne May
Sep 16, 2014·Expert Opinion on Drug Metabolism & Toxicology·Marzia LecchiPaolo Martelletti
Feb 23, 2010·Lancet Neurology·Peter J Goadsby, Till Sprenger
Oct 12, 2010·The Journal of Headache and Pain·Anders Hougaard, Peer Tfelt-Hansen
Apr 20, 2005·Headache·Richard B LiptonJohn N Quiring
Mar 3, 2009·Journal of Clinical Pharmacy and Therapeutics·T J Steiner, M Voelker
Jun 27, 2012·Pain Practice : the Official Journal of World Institute of Pain·Vesile ÖztürkUNKNOWN Mig-Etol Study Group
Jul 11, 2014·Expert Opinion on Pharmacotherapy·Stephen D Silberstein, Jessica C Stirpe
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Christopher J DerryR Andrew Moore
May 2, 2013·The Cochrane Database of Systematic Reviews·Varo KirthiR Andrew Moore
Apr 21, 2006·Expert Review of Neurotherapeutics·Hans-Christoph DienerMichael Voelker
May 14, 2005·Current Opinion in Neurology·Hans-Christoph Diener
Dec 14, 2016·The Journal of Headache and Pain·Haiyang XuMingxian Li
Oct 30, 2020·Journal of Managed Care & Specialty Pharmacy·Foluso AgboolaSteven D Pearson

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