Efficacy of 20% albumin infusion on coagulation and pulmonary fibrosis in rabbits with ARDS

Zhonghua wei zhong bing ji jiu yi xue
Ling YaoFeng Shen

Abstract

To observe the efficacy of 20% albumin infusion on coagulation and pulmonary fibrosis in rabbits with acute respiratory distress syndrome (ARDS) induced by two-hit of intravenous infusion of oleid acid (OA) and lipopolysaccharide (LPS). Forty healthy adult male rabbits were randomly divided into five groups, namely sham group, model group, albumin group (20% albumin), saline group (0.9% sodium chloride injection) and Ringer group (lactate Ringer solution), with 8 rabbits in each group. ARDS model was reproduced by 0.1 mL/kg of OA and 500 μg/kg of LPS through left auricular vein, and the rabbits in sham group were intravenously infused a same volume of saline as the LPS volume given in model group. The rabbits in the three treatment groups were intravenously given corresponding drugs by micro scale pumping following LPS and OA injection through left auricular vein for 210 minutes, but no infusion was given in sham and model groups. The right internal jugular vein blood was collected, and the prothrombin time (PT), active partial prothrombin time (APTT), antithrombin III (ATIII), fibrinogen (Fib) and serum procollagen peptide III (PIIIP) levels were determined at 5, 30, 120 and 210 minutes after model reproduction respectively. E...Continue Reading

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