Abstract
Data on the efficacy of the 23-valent pneumococcal polysaccharide vaccine (PPV-23) in preventing adult community-acquired pneumonia (CAP) among the target population of individuals aged over 65 years and high-risk individuals aged 19-64 years are conflicting. As the Advisory Committee on Immunization Practices (ACIP) has recently demonstrated PPV-23 is likely beneficial to immunocompromised adults by the Grading, Assessment, Development, and Evaluation (GRADE) framework, we conducted meta-analysis to examine its efficacy in an immunocompetent population. We searched the PUBMED, EMBASE, and Cochrane Library databases for randomized trials. Overall relative risks (RRs) with 95% confidential intervals (CIs) were calculated, and the Cochrane Q test (p, I(2)) was performed. Outcomes were assessed by the GRADE framework. Seven randomized trials involving 156,010 participants were included in this meta-analysis. High-quality evidence revealed that PPV-23 was weakly associated with the prevention of all-cause pneumonia ([RR] 0.87, [95%CI] 0.76-0.98, p=0.11, I(2)=43%), especially among the target population ([RR] 0.72, [95%CI] 0.69-0.94, p=0.58 I(2)=0%), the elderly group aged over 40 years ([RR] 0.80, [95%CI] 0.69-0.94) and the Japanes...Continue Reading
References
Jul 27, 1999·Vaccine·P O HonkanenP H Mäkelä
Feb 24, 2001·Epidemiology and Infection·M H KyawH Campbell
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Oct 18, 2005·Thorax·I AlfagemeJ Lima
Nov 22, 2005·Vaccine·Johnna SteentoftJens Rikardt Andersen
Jul 1, 2008·Vaccine·Akitsugu FurumotoKazunori Oishi
Jan 7, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Anke HussMatthias Egger
Jun 16, 2009·Lancet·Tom Jefferson
Jun 25, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K DebbacheC Cordonnier
Feb 12, 2010·American Journal of Public Health·Yue Li, Dana B Mukamel
Mar 10, 2010·BMJ : British Medical Journal·Takaya MaruyamaEsteban C Gabazza
Aug 21, 2010·Vaccine·Kenji KawakamiKazunori Oishi
Aug 21, 2010·American Journal of Public Health·Deron C BurtonUNKNOWN Active Bacterial Core Surveillance/Emerging Infections Program Network
Aug 24, 2010·Thorax·T WelteD Nathwani
Jan 7, 2011·Journal of Clinical Epidemiology·Howard BalshemGordon H Guyatt
Jan 18, 2011·American Journal of Respiratory and Critical Care Medicine·Kevin C Wilson, Holger J Schünemann
Mar 9, 2012·American Journal of Public Health·Shawn A N GilchristOrin Levine
Dec 18, 2012·The West Indian Medical Journal·C D C Christie, R B Pierre
Feb 28, 2013·Human Vaccines & Immunotherapeutics·Aba MahamatBenoît de Wzieres
Apr 9, 2013·PloS One·Maria A SaidJames P Watt
Mar 25, 2014·Annals of Internal Medicine·Carolyn B BridgesUNKNOWN Advisory Committee on Immunization Practices
Jan 13, 2015·Vaccine·Kevin L RussellGregory C Gray
Mar 19, 2015·The New England Journal of Medicine·Marc J M BontenDiederick E Grobbee
Citations
Nov 14, 2016·Vaccine·Daijun ZhaoBin Wu
Dec 29, 2016·International Journal of Molecular Sciences·Nicola Principi, Susanna Esposito
Jan 7, 2017·PloS One·Gerhard FalkenhorstChristian Bogdan
Jan 28, 2017·The Lancet Infectious Diseases·Motoi SuzukiUNKNOWN Adult Pneumonia Study Group-Japan (APSG-J)
Jul 1, 2017·PloS One·Hironori UematsuYuichi Imanaka
Feb 14, 2019·Expert Review of Vaccines·Andrew D WieseCarlos G Grijalva
Jul 4, 2019·Journal of Medical Microbiology·Lucia Gonzales-SilesEdward R B Moore
Jul 16, 2019·Expert Review of Vaccines·Viviane Maimoni GonçalvesEliane Namie Miyaji
Oct 9, 2019·Thorax·Harry PickWei Shen Lim
Oct 14, 2018·BMC Public Health·Akihiro SakamotoMasamitsu Nakazato
Apr 8, 2020·Lung·A Vila-CorcolesX Raga
Jun 18, 2020·Vaccines·Ermias JirruHeather Stout-Delgado
Jan 27, 2017·Arthritis Research & Therapy·Yasumori IzumiKiyoshi Migita
Apr 3, 2018·Epidemiology and Infection·M SuzukiK Morimoto
Jul 25, 2018·Scientific Reports·Hamid Latifi-NavidAli Ahmadi
May 12, 2020·Frontiers in Immunology·Angelika Wagner, Birgit Weinberger
May 13, 2017·PloS One·Jung Yeon HeoJoon Young Song
Apr 9, 2020·Pathogens·Jacob Dag BerildJann Storsäter
Jan 23, 2021·Expert Review of Vaccines·Michael S NiedermanKelly D Johnson
Nov 10, 2020·Vaccine·Jung Yeon HeoJoon Young Song
Dec 18, 2019·Vaccine·Ed ClarkeSteve Lamola
Mar 7, 2020·Archivos de bronconeumología·Rosario MenéndezAntoni Torres
Feb 15, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David Felipe Severiche-BuenoLuis F Reyes
Apr 14, 2021·Value in Health Regional Issues·Jan OlbrechtBaudouin Standaert
Apr 21, 2021·Human Vaccines & Immunotherapeutics·Koichi KobayashiHideaki Nagai
Jul 9, 2021·Expert Review of Vaccines·Lindsay R GrantBradford D Gessner
Oct 11, 2021·Immunity & Ageing : I & a·Birgit Weinberger
Oct 14, 2021·BMC Infectious Diseases·Paula O NarváezLuis Felipe Reyes
Jul 23, 2019·Vaccine·Bradford D GessnerLuis Jodar
Nov 9, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Chun-Yi LuYu-Fan Ho