PMID: 9420307Jan 7, 1998Paper

Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on rhesus macaque monkeys chronically infected with simian immunodeficiency virus (SIVmac239)

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
Y FujiiY Yoshikawa

Abstract

To assess the therapeutic effects of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG), a lipophilic dideoxynucleoside analogue, three rhesus macaques chronically infected with simian immunodeficiency virus (SIVmac239) were subcutaneously administered 25 mg/kg of the drug every 8 hours for 2 weeks. In two of three animals, the viral RNA in plasma and the cell-associated viral load from peripheral blood mononuclear cells were markedly decreased and the number of CD4+ and CD8+ lymphocytes were increased after 6-Cl-ddG administration. The decrease of the virus copies was associated with a reciprocal increase in the number of CD4+ lymphocytes. Additionally, a limiting dilution assay revealed a marked decrease in the lymph node cell-associated virus titer during the treatment. However, in the third monkey, the baseline of the number of CD4+ and CD8+ lymphocytes was higher than that of the other monkeys; these numbers changed very little during the treatment. In this monkey, the plasma SIV RNA level was decreased at the first week and was the same as the pretreatment level at the second week of the 6-Cl-ddG administration. In all three treated monkeys, the number of SIV RNA copies in the cerebrospinal fluid also tended to decrease during th...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·H M McClureR F Schinazi
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T ShirasakaH Mitsuya
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·M E HawkinsF M Balis
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·K V Clemons, D A Stevens
Mar 1, 1994·Journal of Neuropathology and Experimental Neurology·D M RauschL E Eiden

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