PMID: 7538551May 1, 1995Paper

Efficacy of 9-(2-phosphonylmethoxyethyl)adenine treatment against chronic simian immunodeficiency virus infection in macaques

The Journal of Infectious Diseases
C C TsaiN Bischofberger

Abstract

Long-tailed macaques chronically infected with simian immunodeficiency virus (SIV) were treated for 4 or 8 weeks with daily subcutaneous doses of the antiretroviral compound 9-(2-phosphonylmethoxyethyl)adenine (PMEA). The efficacy of PMEA was evaluated by monitoring cell-free virus in plasma, virus titer and viral DNA in peripheral blood mononuclear cells, and absolute numbers of lymphocyte subsets. In mock-treated control macaques, virus titers changed minimally. However, in treated macaques, PMEA exhibited impressive effects, leading to the disappearance of virus in the blood within the first week of treatment and lasting through the fourth week of treatment. The results indicate that PMEA can effectively reduce SIV in chronically infected macaques and offer an optimistic perspective for therapeutic intervention against human immunodeficiency virus infection.

Citations

May 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P A Sandstrom, T M Folks
Mar 6, 1999·Current Opinion in Microbiology·J BalzariniE De Clercq
Sep 10, 2011·AIDS Research and Human Retroviruses·Koen K A Van Rompay
Feb 24, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·K HartmannW Kraft
Apr 29, 2004·Journal of Virology·Koen K A Van RompayNorbert Bischofberger
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