Efficacy of a Combined Treatment of Botulinum Toxin and Intensive Physiotherapy in Hereditary Spastic Paraplegia

Frontiers in Neuroscience
Gabriella PaparellaAndrea Martinuzzi

Abstract

The Hereditary Spastic Paraplegia (HSP) is a heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and lower limbs (LL) weakness. There is no treatment to cure or halt the disease, except for symptomatic therapy. The use of botulinum toxin type A (BoNT-A) is one of the primary treatment for focal spasticity. Physiotherapy (PT) can help in maintaining residual functioning. We performed a retrospective study to evaluate the effect of the combined BoNT-A and intensive PT in patients with HSP. Eighteen adult patients (50% females) with clinical diagnosis of HSP were recruited. Eleven patients had a genetic diagnosis of SPG4, 5, 7, 8, 11, 72. Patients were all autonomously deambulant or needed support. BoNT-A was injected in 36 LL in different spastic muscles under electromyographic guidance and followed by intensive PT sessions. Outcome measures included disease severity, motor functional measures, perceived pain self-report and quality of life. Assessments occurred at baseline, 1 and 3 months after BoNT-A injection. Most inoculated muscles were hamstrings, rectus femoris and gastrocnemius. We observed an improvement in muscle tone, in the gait velocity and distance length. Spastic Paraplegia Ra...Continue Reading

References

Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Feb 1, 1987·Physical Therapy·R W Bohannon, M B Smith
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·J PerryS J Mulroy
Feb 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·J W DunneS L Dunne
Dec 1, 1993·Seminars in Neurology·A E Harding
Jul 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·C McDermottP Shaw
Mar 10, 2001·Archives of Physical Medicine and Rehabilitation·P Rossier, D T Wade
Jul 8, 2005·Journal of Clinical Nursing·Amelia Williamson, Barbara Hoggart
Jan 26, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M RousseauxW Daveluy
Nov 14, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Martin J HechtUNKNOWN German Spasticity Education Group
Apr 5, 2008·Journal of Neural Transmission·A B Ward
Apr 22, 2010·Journal of Child Neurology·Keren Geva-DayanAviva Fattal-Valevski
Sep 11, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Luigi PiccininiManuela Galli
Jun 24, 2014·Experimental Neurology·Temistocle Lo GiudiceAntonio Orlacchio
Dec 3, 2014·Archives of Physical Medicine and Rehabilitation·Richard W BohannonRichard C Gershon
Dec 10, 2015·Current Pharmaceutical Design·Marvulli RiccardoMegna Marisa
Jun 9, 2016·The Cerebellum·Paulo Victor Sgobbi de SouzaAcary Souza Bulle Oliveira
May 29, 2018·Arquivos de neuro-psiquiatria·Katiane R ServelhereMarcondes C França
May 31, 2018·Current Opinion in Neurology·Livia ParodiAlexandra Durr

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Citations

Feb 18, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Fabricio Diniz de LimaMarcondes C França
Jul 11, 2021·The Cerebellum·Diana Maria Cubillos-ArcilaJonas Alex Morales Saute
Jul 25, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Fabricio Diniz de Lima, Marcondes C França

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