PMID: 6404440Apr 23, 1983Paper

Efficacy of a heat inactivated hepatitis B vaccine in male homosexuals: outcome of a placebo controlled double blind trial

British Medical Journal
R A CoutinhoH W Reesink

Abstract

The efficacy of a heat inactivated hepatitis B virus vaccine, containing 3 micrograms hepatitis B surface antigen (HBsAg), was studied in a high risk group of 800 susceptible homosexual men by a randomised placebo controlled double blind trial. At the trial end point (21.5 months), 17 hepatitis B virus infections had occurred in vaccinated subjects (attack rate 4.8%) and 56 in subjects receiving a placebo (attack rate 23.8%). This reduction in the incidence of hepatitis B virus infections in vaccinated subjects was highly significant (p less than 0.0001). Two months after the first injection 72.3% of the vaccinated subjects had formed antibodies against hepatitis B surface antigen, and this percentage increased to 89% at four months. Maximum anti-HBs titres were reached five months after the first vaccination, the geometric mean titre being 107.6 mIU. Even vaccinated subjects with a low antibody response (greater than or equal to 1 and less than 10 mIU) were found to be protected from HBsAg-positive infections. The vaccine had no serious side effects.

References

Oct 1, 1975·Annals of Internal Medicine·W SzmunessG H Block
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Citations

Jan 1, 1993·Vaccine·A R ZanettiI Grappasonni
Jul 24, 1986·The New England Journal of Medicine·S C HadlerN L Altman
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C L KuikenJ Goudsmit
May 18, 2010·Nephrology·Matthew EdeyDavid W Johnson
Dec 10, 1983·British Medical Journal·R A CoutinhoT Rijsdijk
Jan 28, 1989·BMJ : British Medical Journal·G J van GriensvenR A Coutinho
Jul 13, 1991·BMJ : British Medical Journal·N BhattiI V Weller
Aug 1, 1984·The British Journal of Venereal Diseases·R A CoutinhoJ van der Noordaa
Apr 1, 1985·Genitourinary Medicine·C L GohV S Rajan
Aug 1, 1992·Digestive Diseases and Sciences·D H Van ThielT E Starzl
Oct 1, 1994·European Journal of Epidemiology·D Palmović, J Crnjaković-Palmović
Nov 1, 1985·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·U BienzleI Guggenmoos-Holzmann
Sep 4, 1989·The American Journal of Medicine·C Goilav, P Piot
Dec 20, 2014·Medical Microbiology and Immunology·Wolfram H Gerlich
Feb 4, 2010·Clinics in Liver Disease·Abigail L Carlson, Trish M Perl
Jan 12, 1984·Nature·W J McAleerM R Hilleman
Dec 15, 1993·Cancer·C Mahler
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May 1, 1990·Journal of Gastroenterology and Hepatology·N C Tassopoulos, G J Papaevangelou

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