Efficacy of a modified coagulation factor substitution for total hip arthroplasty in patients with end-stage haemophilic arthropathy

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Ji-liang ZhaiShigong Guo

Abstract

Total hip arthroplasty (THA) is an effective treatment for end-stage haemophilic arthropathy, and substitution therapy plays a key role in the success of THA. The aim of this study was to evaluate the efficacy of a modified coagulation factor substitution regime in THA. Nineteen haemophiliac patients (20 hips) who received primary cementless THA were enrolled. Based on World Federation of Haemophilia (WFH) guideline, a modified coagulation factor substitution regime was adopted. Blood loss, implant survival rates and complications were reviewed, retrospectively. The mean age at surgery was 29.7 years (15-49 years) and the mean follow-up period was 91 months (43-151 months). Mean total blood loss, external blood loss and hidden blood loss were 3543 (1494-7576), 1435 (600-3440), and 2110 ml (534-4402), respectively. Mean intraoperative blood loss and postoperative drainage were 715 (300-2000) and 713 ml (200-2950), respectively. Mean red blood cell transfusion used was 5 U (0-14). All prostheses were found to have bony ingrowth. One patient had hematoma formation in the thigh and one with a lower limb deep vein thrombosis, postoperatively. Other complications included one skin ulcer, one femur splitting fracture, and one transien...Continue Reading

References

Aug 1, 1996·Acta Orthopaedica Scandinavica·T LöfqvistI M Nilsson
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·M HeegJ Van der Meer
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Nov 6, 2012·The Journal of Arthroplasty·S M Javad MortazaviJavad Parvizi
Oct 10, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·S H LeeY S Chun
May 23, 2015·The Journal of Arthroplasty·Christian CarulliMassimo Innocenti

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