PMID: 11929393Apr 4, 2002Paper

Efficacy of a motilin receptor agonist (ABT-229) for the treatment of gastro-oesophageal reflux disease

Alimentary Pharmacology & Therapeutics
C L ChenR J Mack

Abstract

ABT-229 is a potent motilin agonist without significant antibiotic activity. It has been shown to improve gastric emptying in humans and to increase lower oesophageal sphincter pressure in cats. To assess the efficacy of four different doses of ABT-229 (1.25 mg, 2.5 mg, 5 mg, 10 mg b.d.) compared to placebo in the treatment of gastro-oesophageal reflux disease, and to determine its safety in patients with gastro-oesophageal reflux disease. In a double-blind, multicentre study, 324 patients with heartburn were randomized to receive four different doses of ABT-229 or placebo for 8 weeks. The efficacy was evaluated by Patient Symptom Questionnaire, daily diary, endoscopy and global evaluation of efficacy. There were no statistically significant improvement scores for any of the ABT-229 treatment groups vs. the placebo group in any of the efficacy parameters. Reflux symptom scores were significantly worse after treatment in the dyspeptic group. ABT-229 appeared to be well tolerated and safe in total daily doses up to 20 mg. ABT-229 appears to have limited, if any, clinical utility in the treatment of gastro-oesophageal reflux disease.

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Citations

May 26, 2005·Current Gastroenterology Reports·Sara Emerenziani, Daniel Sifrim
Apr 29, 2010·Current Gastroenterology Reports·Paul Kuo, Richard H Holloway
Feb 11, 2005·Current Opinion in Gastroenterology·Nam Q Nguyen, Richard H Holloway
Feb 26, 2009·Digestive Diseases and Sciences·V MertensD Sifrim
Dec 24, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M-I ParkA R Zinsmeister
May 12, 2009·Pharmacology & Therapeutics·Betty De SmetInge Depoortere
Jul 20, 2006·Digestive Diseases·G Karamanolis, J Tack
Jan 25, 2019·Nature Reviews. Endocrinology·Eveline DelooseJan Tack

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