Efficacy of a novel device for assessment of autonomic sensory function in the rat bladder.

The Journal of Urology
Robert AbouassalyFirouz Daneshgari

Abstract

We developed and tested the efficacy of an implantable bladder device which, when combined with the Neurometer, can be used to assess fiber specific afferent bladder sensation in the rat. We developed an implantable bladder device that applies selective nerve fiber stimuli (250 Hz for small myelinated Adelta fibers and 5 Hz for unmyelinated C fibers) to the bladder mucosa in the rat to determine bladder sensory perception threshold values. We performed 3 experiments in 55 female Sprague-Dawley rats to examine the effects of our device on voiding habits, assess the interobserver reliability of the sensory perception threshold and determine the effects of intravesical administration of resiniferatoxin (Sigma) and lidocaine on the sensory perception threshold. Sensory perception threshold values obtained by 2 blinded, independent observers were not different from each other (p = 0.41). Sensory perception threshold values obtained at the 2 stimulation frequencies remained constant for at least 3 weeks after device implantation. A significant increase in sensory perception threshold values after resiniferatoxin instillation was noted at a stimulus frequency of 5 Hz (p = 0.02), whereas intravesical lidocaine led to an immediate incre...Continue Reading

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Citations

Mar 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yukio HayashiNaoki Yoshimura
Jun 25, 2014·Urology·Fuat BicerGuiming Liu
Dec 6, 2011·Urology·Yasuhiro YamadaFirouz Daneshgari
Jul 2, 2011·European Urology·Cengiz Z AltuntasVincent K Tuohy
Jun 24, 2010·Physiology & Behavior·Tomonari WatabikiTony L Yaksh
May 1, 2010·Neurourology and Urodynamics·C H FryL A Birder
Jan 16, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Nan XiaoGuiming Liu
Aug 10, 2010·Annals of Neurology·Iain PerkesDavid K Menon

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