PMID: 9187886May 1, 1997Paper

Efficacy of a pectin-based anti-reflux agent on acid reflux and recurrence of symptoms and oesophagitis in gastro-oesophageal reflux disease

European Journal of Gastroenterology & Hepatology
T HavelundL Rasmussen

Abstract

Gastro-oesophageal reflux disease may be treated with a drug forming a floating neutral raft in the stomach. The pectin-based raft-forming anti-reflux agent Aflurax (Idoflux) was examined, first regarding reduction of oesophageal acid exposure, and next as to its efficacy as maintenance treatment in patients with healed oesophagitis. Double-blind, placebo-controlled randomized clinical trials. Open access endoscopy unit. Fourteen patients with erosive oesophagitis had measurement of acid exposure. Eighty-eight patients with healed erosive/ulcerative oesophagitis and relief of heartburn after pre-treatment with omeprazole received maintenance treatment. Crossover 12-h oesophageal pH monitoring during Aflurax/placebo treatment. Maintenance treatment for up to 6 months with two tablets of Aflurax 1200 mg or placebo four times daily. Percentage time pH less than 4 in 6 plus 6 h (upright + supine). Time to recurrence of moderate or severe heartburn (life table analysis). The median (interquartile range) acid exposure times in the upright position were: 3.1% (1.6-13.0%) on Aflurax versus 6.7% (2.5-14.9%) on placebo (P = 0.10). In the supine position no difference was found (Aflurax 13.7%, placebo 13.2%). The time to recurrence of hea...Continue Reading

Citations

Feb 24, 2001·Journal of Gastroenterology and Hepatology·K AmanoY Kinoshita
Dec 22, 2007·Drug Development and Industrial Pharmacy·Chhanda J Kapadia, Vidya B Mane
Jun 10, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Orazio Luca StrusiPaolo Colombo
Jan 13, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·P L BardonnetF Falson
Aug 2, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M BouinP Ducrotté
Feb 19, 2010·The Cochrane Database of Systematic Reviews·Clare DonnellanNav Sharma

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