Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Surjyo Jyoti BiswasAnisur Rahman Khuda-Bukhsh

Abstract

Ethanolic whole plant extract of Chelidonium majus, extensively used in traditional systems of medicine against various liver ailments, has been tested for its possible anti-tumor, hepato-protective and anti-genotoxic effects in p-dimethylaminoazobenzene (p-DAB) induced hepatocarcinogenesis in mice through multiple assays: cytogenetical, biochemical, histological and electron microscopical. Different sets of mice, 5 (for 7, 15 and 30 days' treatment) or 10 (for 60, 90 and 120 days) each, were chronically fed a diet suitably mixed with p-DAB and phenobarbital to develop liver tumors. One sub-group of carcinogen fed mice was also fed C. majus extract; 0.1 ml daily (drug-treated) while the other equal amount of dilute ethyl alcohol ("vehicle" of plant extract) (positive control). A separate group of mice was maintained with normal diet without any carcinogen treatment (negative control). Data of several cytogenetical endpoints and biochemical assay of some toxicity marker enzymes at all fixation intervals and histology of liver sections through ordinary, scanning and transmission electron microscopy at 60 and 120 days and that of spleen and kidney at 90 days were critically analyzed in the treated lots vis-a-vis controls. The resu...Continue Reading

References

May 1, 1991·Biochemical Pharmacology·N E PreeceJ A Timbrell
Jan 1, 1989·Journal of Toxicology and Environmental Health·B A SchaumannM Pederson
Jan 1, 1986·Toxicology and Applied Pharmacology·D P EvensonR W Gesch
Jul 1, 1970·Journal of Comparative Pathology·J S Fowler
Jan 1, 1982·Journal of Natural Products·M Suffness, J Douros
Sep 1, 1981·Journal of Medicinal Chemistry·D WalterováJ Lasovský
Dec 7, 1993·Biochemistry·J Wolff, L Knipling
Feb 1, 1996·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M L Colombo, E Bosisio
Mar 31, 1998·Environmental Health Perspectives·J E KlaunigE F Walborg
Feb 15, 2001·Japanese Journal of Cancer Research : Gann·S OhnishiS Kawanishi
Jun 8, 2001·The International Journal of Biochemistry & Cell Biology·F CaballeroE Vazquez
Dec 18, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·D C TavaresC S Takahashi
Apr 12, 2002·BMC Complementary and Alternative Medicine·Surjyo Jyoti Biswas, Anisur Rahman Khuda-Bukhsh
Jan 8, 2003·Seminars in Oncology·Mary Ann Richardson, Stephen E Straus
Apr 12, 2003·Epilepsia·Carlo BelliniEugenio Bonioli
Nov 19, 2003·Molecular and Cellular Biochemistry·Anisur Rahman Khuda-Bukhsh
Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Pavel KosinaVilím Simánek
Oct 6, 2005·Mutation Research·Surjyo Jyoti Biswas, Anisur Rahman Khuda-Bukhsh
Nov 22, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Surjyo Jyoti BiswasAnisur Rahman Khuda-Bukhsh
Mar 16, 2006·Molecular and Cellular Biochemistry·Surajit PathakAnisur Rahman Khuda-Bukhsh
Nov 15, 2006·Integrative Cancer Therapies·Anisur R Khuda-Bukhsh
Dec 27, 2006·Experimental and Molecular Pathology·Surajit Pathak, Anisur Rahman Khuda-Bukhsh
Jun 29, 2007·Forschende Komplementärmedizin = Research in Complementary Medicine·Surajit PathakAnisur Rahman Khuda-Bukhsh

❮ Previous
Next ❯

Citations

Aug 27, 2013·Journal of Acupuncture and Meridian Studies·Asmita SamadderAnisur Rahman Khuda-Bukhsh
Aug 7, 2012·BMC Complementary and Alternative Medicine·Rahmat A KhanShumaila Jan
Jan 22, 2011·Journal of Occupational Medicine and Toxicology·Céline GasnierGilles-Eric Séralini
Aug 5, 2009·World Journal of Gastroenterology : WJG·Sakineh Kazemi Noureini, Michael Wink
Apr 30, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Joabe Gomes de MeloUlysses Paulino de Albuquerque
Aug 1, 2008·Expert Opinion on Drug Discovery·Anisur Rahman Khuda-Bukhsh, Surajit Pathak
Aug 3, 2010·Homeopathy : the Journal of the Faculty of Homeopathy·Antara BanerjeeAnisur Rahman Khuda-Bukhsh
Dec 1, 2009·Homeopathy : the Journal of the Faculty of Homeopathy·Anisur Rahman Khuda-Bukhsh
Oct 9, 2009·Ecotoxicology and Environmental Safety·Abhishek MukherjeeAnisur R Khuda-Bukhsh
Sep 19, 2009·Journal of Ethnopharmacology·Gabriela MazzantiAnnabella Vitalone
Sep 2, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu-Wen HsuFung-Jou Lu
Aug 18, 2012·Journal of Acupuncture and Meridian Studies·Nandini Bhattacharjee, Anisur Rahman Khuda-Bukhsh
Oct 14, 2018·Environmental Toxicology·Mabrouk Attia Abd EldaimWalaa Mohamed Awd
Apr 16, 2019·PloS One·Helen PourmazaheriMohammad Reza Naghavi
Mar 4, 2020·International Journal of Environmental Research and Public Health·Joanna NawrotJustyna Gornowicz-Porowska
Feb 11, 2021·International Journal of Molecular Sciences·Dahye YunYoon Jung Park
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ehab ToussonAlaa A Ahmed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.