Efficacy of a prehospital self-expanding polyurethane foam for noncompressible hemorrhage under extreme operational conditions

The Journal of Trauma and Acute Care Surgery
Adam P RagoDavid R King

Abstract

Noncompressible abdominal hemorrhage is a significant cause of battlefield and civilian mortality. We developed a self-expanding polyurethane foam intended to provide temporary hemorrhage control and enable evacuation to a definitive surgical capability, for casualties who would otherwise die. We hypothesized that foam treatment would be efficacious over a wide range of out-of-hospital operational conditions. The foam was tested in an established lethal, closed-cavity hepatoportal injury model in four groups as follows. Group 1 involved baseline conditions, wherein foam was deployed from a pneumatically driven, first-generation delivery device at room temperature (n = 6). Group 2 involved foam deployment from a field-relevant, handheld delivery prototype (n = 12). Group 3 involved foam components that were conditioned to simulate 1-year shelf-life (n = 6). Group 4 involved foam that was conditioned to a range of temperatures (10 °C and 50 °C; n = 6 per group). In all studies, survival was monitored for up to 180 minutes and compared with an ongoing and accumulating control group with no intervention (n = 14). In Group 1 with a first-generation delivery system, foam treatment resulted in a significant survival advantage relative...Continue Reading

References

Jan 20, 2004·Injury·Betty J Tsuei, Paul A Kearney
May 25, 2007·Annals of Surgery·John B HolcombFrank K Butler
Apr 12, 2008·The Journal of Trauma·Peter RheeHassan Alam
Nov 26, 2010·The British Journal of Surgery·A StannardN R Tai
Aug 4, 2011·The Journal of Trauma·Brian J EastridgeLorne H Blackbourne
Aug 17, 2011·Archives of Surgery·Russ S KotwalJohn B Holcomb
Aug 2, 2012·The Surgical Clinics of North America·Jonathan J Morrison, Todd E Rasmussen
Aug 28, 2012·The Journal of Surgical Research·Michael J DugganDavid R King
May 23, 2013·The Journal of Trauma and Acute Care Surgery·Michael DugganDavid R King
Jul 9, 2013·The Journal of Surgical Research·Mehreen KisatAdil H Haider
Sep 18, 2013·The Journal of Trauma and Acute Care Surgery·Jonathan J MorrisonMark J Midwinter
Jan 9, 2014·The Journal of Surgical Research·Michael J DugganDavid R King
Feb 21, 2014·The Journal of Trauma and Acute Care Surgery·Miroslav P PeevDavid Richard King
Jul 1, 2014·The Journal of Trauma and Acute Care Surgery·Adam RagoDavid Richard King

❮ Previous
Next ❯

Citations

Feb 19, 2016·Traffic Injury Prevention·Juliet J RayCarl I Schulman
Apr 23, 2016·Transfusion·Joseph F Rappold, Grant V Bochicchio
Jul 8, 2016·Acta chirurgica Belgica·Martin Lucien TongletStephane Degesves
Mar 5, 2020·The British Journal of Surgery·M W Wandling, B A Cotton
Sep 18, 2020·Advanced Healthcare Materials·Sara PourshahrestaniAldo R Boccaccini
May 19, 2021·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Matilda K BjörklundKatie Gillies

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.