Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model

Nature Communications
Jorge C G BlancoTrudy G Morrison

Abstract

Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants. Maternal immunization is an option to increase maternal antibody levels and protect infants from infection. Here we assess the efficacy of virus-like particle (VLP) vaccine candidates containing stabilized pre-fusion (pre-F) or post-fusion (post-F) conformations of the RSV F protein and the attachment RSV G protein in a maternal immunization model using cotton rats. VLP vaccines containing RSV F and G proteins strongly boost pre-existing RSV immunity in dams preventing their perinatal drop in immunity. Boosting is stronger for the pre-F VLP than for the post-F VLP or purified subunit F protein vaccines, giving an advantage on mothers' protection. VLP immunization of dams provides significant protection to pups from RSV challenge and reduced pulmonary inflammation. Collectively, our results show that a VLP vaccine with RSV F and G proteins is safe and effective for maternal and adult vaccination.

References

Oct 1, 1983·Infection and Immunity·G A PrinceR M Chanock
Jun 8, 2007·Journal of Comparative Pathology·J A Englund
Feb 26, 2010·Journal of Virology·Lori W McGinnesTrudy G Morrison
Jun 7, 2014·The Journal of Infectious Diseases·Helen Y ChuJanet A Englund
Sep 4, 2015·Vaccine·Jorge C G BlancoMarina S Boukhvalova
Oct 21, 2015·Emerging Infectious Diseases·Sarahn M WheelerGeeta K Swamy
Apr 24, 2016·Vaccine·Deborah HigginsCheryl Keech

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Citations

Jul 7, 2019·Vaccines·Sarah WilmschenJanine Kimpel
Oct 8, 2019·Expert Review of Vaccines·Iebe Rossey, Xavier Saelens
Jan 7, 2020·Expert Review of Vaccines·Fu-Shi QuanSang-Moo Kang
Aug 19, 2020·Expert Opinion on Pharmacotherapy·Alexis M KalergisSusan M Bueno
Oct 28, 2019·Frontiers in Immunology·Lydia J AthertonRalph A Tripp
Feb 26, 2020·Pathogens·Daniela Ogonczyk MakowskaGuy Boivin
Dec 22, 2020·Future Virology·Laura M Stephens, Steven M Varga
Dec 30, 2020·Vaccines·Nicholas W Lukacs, Carrie-Anne Malinczak
Jun 1, 2021·Frontiers in Immunology·Miguel Ángel Palacios-PedreroGiulietta Saletti

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Methods Mentioned

BETA
ELISA
PCR
serum collection

Software Mentioned

KaleidaGraph
SoftMax Pro
GraphPad Prism

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