PMID: 3760274Sep 1, 1986Paper

Efficacy of a sunscreen containing butyl methoxydibenzoylmethane against ultraviolet A radiation in photosensitized subjects

Journal of the American Academy of Dermatology
R W GangeR DeGryse

Abstract

Topical formulations containing a new chemical entity, the ultraviolet A absorber Parsol 1789 (butyl methoxydibenzoylmethane), were evaluated as agents for protecting human skin against ultraviolet A (UVA) radiation. Healthy subjects were photosensitized to UVA radiation by ingestion of 8-methoxypsoralen (0.6 mg/kg). After 90 minutes, five formulations (vehicle, vehicle + butyl methoxydibenzoylmethane, vehicle + butyl methoxydibenzoylmethane + padimate O, vehicle + padimate O, and a marketed sunscreen containing padimate O, oxybenzone, and octyl salicylate) were applied in a randomized, double-blind manner to areas on the lower part of the back. Thirty minutes later, sites in the five treated areas and in a sixth unprotected area were exposed to graduated doses of UVA radiation. Test sites were evaluated for erythema 48 and 72 hours after UVA exposure, and for melanogenesis approximately 2 weeks later. The combination of butyl methoxydibenzoylmethane + padimate O demonstrated significantly greater protection than the combination of padimate O, oxybenzone, and octyl salicylate.

References

Jan 1, 1983·Archives of Dermatological Research·F GschnaitI Ladich
Jul 1, 1982·The British Journal of Dermatology·D J CrippsA B Lerner

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Citations

Jan 1, 1991·Archives of Dermatological Research·J A Johnson
Jun 2, 2005·Journal of the American Academy of Dermatology·Prisana Kullavanijaya, Henry W Lim
Jul 1, 1989·Journal of the American Academy of Dermatology·R RoelandtsM Garmyn
Jan 23, 1999·Clinical and Experimental Dermatology·R Roelandts
Jul 1, 1990·International Journal of Dermatology·J M Menter
Aug 1, 1992·International Journal of Dermatology·J Dobak, F T Liu
Dec 16, 1998·Australian and New Zealand Journal of Medicine·C G HaydenH A Benson
Oct 1, 1990·The Journal of Dermatologic Surgery and Oncology·N J Lowe
Mar 1, 1992·Clinical and Experimental Dermatology·K GreavesD J Cripps
Apr 16, 1998·The Journal of Investigative Dermatology·T TakeuchiE F Bernstein
Aug 1, 1991·Journal of the American Academy of Dermatology·K H Kaidbey, A Barnes
May 1, 1991·Journal of the American Academy of Dermatology·R M Fusaro, J A Johnson
Jun 1, 1989·Journal of the American Academy of Dermatology·R D FurukawaC A Ramsay
Jan 1, 1990·Journal of the American Academy of Dermatology·C R TaylorB A Gilchrest
Jul 1, 1989·Clinics in Dermatology·C A Ramsay
Jul 1, 1988·Clinics in Dermatology·N J LoweM Wortzman
May 1, 1987·Contact Dermatitis·A C de Groot, J W Weyland
May 1, 1989·Journal of the American Academy of Dermatology·J W StanfieldL Krochmal
May 1, 1994·Journal of the American Academy of Dermatology·C Cole
Feb 1, 1987·Contact Dermatitis·A C de GrootJ W Weyland

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