Efficacy of a synthetic mesh sling in keeping the small bowel in the upper abdomen to prevent radiation enteropathy in gynecologic malignancies

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Y M van KasterenP Kenemans

Abstract

Radiation therapy in gynecological malignancies is limited by the frequent occurrence of radiation enteropathy at effective dose levels of 45 Gy and higher. Elevation of the small bowel out of the true pelvis should enable doses of up to 60-70 Gy to be given without damaging the small bowel. We report a feasibility study concerning elevation of the small bowel out of the true pelvis, by creating an intra-abdominal sling with a synthetic mesh. Twelve patients with pelvic gynecological malignancies were included since 1986. In all patients peroperative application of the mesh was possible. In ten patients adequate elevation of the small bowel was achieved. Two patients showed a right-sided herniation of a small bowel loop on a control barium opacification, performed 1 week postoperatively. In one of these a fistula occurred after resecuring the mesh. The most important problem in this study, as has also been reported elsewhere, was a herniation of a small bowel loop. The incidence is probably inversely correlated with the skill of the surgeon and will therefore be reduced with increasing experience. Future long-term studies should address the issue whether or not radiation enteropathy can be prevented by this method.

References

Jul 1, 1977·American Journal of Surgery·L MorgensternN B Friedman
Sep 1, 1975·Gynecologic Oncology·G J JuillardM L Smith
Mar 1, 1991·Archives of Surgery·K S Dasmahapatra, A P Swaminathan
Jun 1, 1989·Surgery, Gynecology & Obstetrics·S F SenerM Meiselman
Feb 1, 1988·American Journal of Clinical Oncology·M I FeldmanS Choe
Jan 1, 1988·Diseases of the Colon and Rectum·D F DevereuxL Zinkin
Feb 1, 1986·International Journal of Radiation Oncology, Biology, Physics·H ItoL Milas
Jun 1, 1984·Journal of Surgical Oncology·D F DevereuxP J Mozden
Mar 1, 1983·International Journal of Radiation Oncology, Biology, Physics·A D HambergerG H Fletcher
Jan 1, 1984·International Journal of Radiation Oncology, Biology, Physics·J E RussJ D Gagnon
Apr 1, 1983·International Journal of Radiation Oncology, Biology, Physics·R J Caspers, W C Hop

❮ Previous
Next ❯

Citations

Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·J C RoeskeA J Mundt
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Arno J MundtJohn C Roeske
Jun 5, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E. D. ReisT. Heimann
Dec 7, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Y PointreauI Barillot
Jun 26, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M FirouzmandP Maingon
Feb 1, 1997·The Surgical Clinics of North America·T J Saclarides

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.