Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak.

Journal of the American Medical Directors Association
Hubert BlainJean Bousquet

Abstract

To assess the American Testing Guidance for Nursing Homes (NHs)-updated May 19, 2020-with a new COVID-19 case. Case investigation. All 79 residents and 34 health care personnel (HCP) of an NH. Seven days after identification of a COVID-19 resident, all residents and HCP underwent real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) testing for SARS-CoV-2 with nasopharyngeal swabs. This was repeated weekly in all previously negative subjects until the testing identified no new cases, and in all positive subjects until the testing was negative. COVID-19 infection prevention and control (IPC) measures were implemented in all residents and HCP with positive testing or with COVID-19 symptoms. Standard IPC was also implemented in all HCP. Six weeks after initial testing, all residents underwent testing for enzyme-linked immunosorbent assay-based IgG antibodies directed against the SARS-CoV-2. Symptoms were serially recorded in residents and HCP. A total of 36 residents had a positive rRT-PCR at baseline and 2 at day 7. Six HCP had a positive rRT-PCR at baseline and 2 at day 7. No new COVID-19 cases were diagnosed later. Among the SARS-CoV-2-positive cases, 6 residents (16%) and 3 HCP (37%) were asymptomatic during the ...Continue Reading

References

Mar 29, 2020·The New England Journal of Medicine·Temet M McMichaelUNKNOWN Public Health–Seattle and King County, EvergreenHealth, and CDC COVID-19 Investigation Team
Apr 25, 2020·The New England Journal of Medicine·Melissa M AronsUNKNOWN Public Health–Seattle and King County and CDC COVID-19 Investigation Team
May 7, 2020·JAMA : the Journal of the American Medical Association·Nandini SethuramanAkihide Ryo

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Citations

Sep 12, 2020·Annals of Internal Medicine·Roger ChouAnnette M Totten
Nov 4, 2020·European Geriatric Medicine·Hubert BlainAthanase Benetos
Oct 27, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Cameron G Gmehlin, L Silvia Munoz-Price
Dec 29, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Shalabh KumarPraveen Kumar Arumugam
Feb 22, 2021·Revista española de geriatría y gerontología·Alain García-de CastroFernando Lamelo-Alfonsín
Mar 16, 2021·Annals of Internal Medicine·Irina Arkhipova-JenkinsKatherine Mackey
Jul 9, 2021·Journal of the American Medical Directors Association·Anne-Laure CoudercAurélie Daumas
Dec 2, 2020·Journal of the American Medical Directors Association·Christine E KistlerSheryl Zimmerman
Aug 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Pratha SahAlison P Galvani
Aug 25, 2021·Journal of the American Medical Directors Association·Sally Hall DykgraafMichael Kidd
Apr 4, 2021·Allergy·Jean BousquetLudger Klimek

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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