Efficacy of adjunctive high frequency repetitive transcranial magnetic stimulation of left prefrontal cortex in depression: a randomized sham controlled study

Journal of Affective Disorders
Sanjukta RayMohammad Zia-ul-Haq

Abstract

To examine the efficacy of adjunctive left prefrontal high-frequency rTMS treatment in depression patients as compared to sham stimulation. 45 right handed moderate to severe depression patients according to ICD-10 DCR criteria were randomized to receive daily sessions of active or sham rTMS (10Hz, 90% of resting MT, 20 trains, 6s duration, 1200 pulses/day) over the right dorsolateral prefrontal cortex for 10 days. Depression and psychosis was rated using Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D) and Brief Psychiatric Rating Scale (BPRS) respectively before and after rTMS. For SIGH-D scores, repeated measures ANOVA showed a significant effect of treatment over time as shown by interaction effect (Pillai's Trace F [1/38] = 56.75, p<.001, η(2) = .60). For BPRS, repeated measures ANOVA showed a significant interaction effect of treatment over time (Pillai's Trace F [1/38] = 39.87, p<.001, η(2) = .51). In psychotic depression patients, repeated measures ANOVA showed a significant effect of treatment over time for SIGH-D scores (Pillai's Trace F [1/25] = 43.04, p<.001, η(2) = .63) and BPRS scores (Pillai's Trace F [1/25] = 42.17, p<.001, η(2) = .63). High-frequency left prefrontal rTMS was well tol...Continue Reading

Citations

Feb 22, 2012·Indian Journal of Psychological Medicine·Samir Kumar Praharaj
Mar 1, 2014·Revista colombiana de psiquiatría·Mayra MalaveraSandra Carrillo
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Jul 3, 2013·Journal of Affective Disorders·Gretchen J DiefenbachJohn W Goethe
Jan 12, 2017·Trends in psychiatry and psychotherapy·Renata de Melo Felipe, Ygor Arzeno Ferrão
May 1, 2018·Frontiers in Human Neuroscience·Wing Ting ToSven Vanneste
Jan 23, 2021·Neuroscience and Biobehavioral Reviews·Stephanie HomanPhilipp Homan

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