Efficacy of alemtuzumab and natalizumab in the treatment of different stages of multiple sclerosis patients

Medicine
Li WangQiu-Yue Zhong

Abstract

Multiple sclerosis (MS) is an autoimmune disease, in which the insulating covers of nerve cells in the brain and spinal cord are demyelinated. This study was conducted to compare the efficacy of alemtuzumab and natalizumab in the treatment of different stages of MS patients. A total of 585 patients diagnosed with MS and hospitalized were included and analyzed after which they were divided into the primary progressive MS A and B groups, the relapsing-remitting MS (RRMS) C and D groups, and the secondary progressive MS E and F groups. Patients in A, C, and E groups were administered alemtuzumab while those in B, D, and F groups were administered natalizumab for the treatment. The expanded disability status scale (EDSS) scores and the EDSS difference were calculated before and after treatment. The number of head magnetic resonance imaging enhanced lesions in the patients, recurrence time and recurrence rate were measured before and after treatment. The EDSS score of the RRMS group was significantly lower than that of the primary progressive MS group and the secondary progressive MS group. After 12 months of treatment, the EDSS score of RRMS patients treated with natalizumab was significantly lower compared with the patients with a...Continue Reading

References

Feb 1, 1975·Acta Neurologica Scandinavica·J F Kurtzke
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Mar 3, 2006·The New England Journal of Medicine·Chris H PolmanUNKNOWN AFFIRM Investigators
Mar 14, 2007·Journal of the Neurological Sciences·June Halper
Feb 8, 2008·The New England Journal of Medicine·John T MullenMichael B Atkins
Jun 7, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·H TremlettUNKNOWN UBCMS Clinic Neurologists
Sep 23, 2008·Trends in Pharmacological Sciences·Ralf A LinkerRalf Gold
Oct 24, 2008·The New England Journal of Medicine·Alasdair J ColesP K Tandon
Jan 1, 2007·Recent Patents on Inflammation & Allergy Drug Discovery·Abbas Mirshafiey
Sep 30, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rachel A Farrell, Gavin Giovannoni
Apr 21, 2012·Lancet Neurology·Jeffrey A CohenUNKNOWN International Advisory Committee on Clinical Trials in Multiple Sclerosis
Oct 10, 2012·Nature Reviews. Neurology·Markus KrumbholzEdgar Meinl
Nov 28, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alasdair J Coles
Jan 30, 2013·Nature Reviews. Neurology·Heinz Wiendl, Bernd Kieseier
Sep 15, 2014·Clinical Therapeutics·Michael D Carrithers
Oct 11, 2014·Internal Medicine Journal·L SedalE A McDonald
Feb 24, 2015·Cytokine·Dusanka S SkundricHarley Y Tse
Nov 14, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Ø TorkildsenL Bø
Nov 14, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stefan Bittner, Heinz Wiendl
Dec 25, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jens IngwersenHans-Peter Hartung
Apr 27, 2016·Practical Neurology·Gavin GiovannoniKlaus Schmierer
Aug 24, 2016·BMJ : British Medical Journal·Dean M Wingerchuk, Brian G Weinshenker
Oct 6, 2016·Medical Microbiology and Immunology·Alessandra BuaPaola Molicotti
Nov 29, 2016·Acta Neurologica Scandinavica·P Soelberg Sorensen
Feb 10, 2017·Drugs·Gregory HeathRichard Peter Gale

❮ Previous
Next ❯

Citations

Jan 16, 2019·Reviews in the Neurosciences·Tomasz Grzegorski, Jacek Losy
Nov 6, 2020·International Journal of Environmental Research and Public Health·Kora Portilla-CuetoJosé Antonio de Paz

❮ Previous
Next ❯

Software Mentioned

SPSS19

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
D FacchettiM Poloni
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Jose Manuel Abalo-LojoFrancisco Gonzalez
© 2022 Meta ULC. All rights reserved