Efficacy of allopurinol pretreatment for prevention of contrast-induced nephropathy: a randomized controlled trial

International Journal of Cardiology
T ErolH Müderrisoğlu

Abstract

Contrast-induced nephropathy (CIN) remains a common complication of radiographic procedures. Radiocontrast agents can cause a reduction in renal function that may be due to reactive oxygen species. Conflicting evidence suggests that administration of antioxidants prevents CIN. We assessed the efficacy of allopurinol in preventing CIN. We prospectively randomized 159 patients with a serum creatinine concentration >1.1mg/dL undergoing cardiac catheterization/interventions to receive allopurinol (300 mg, p.o.) 24h before administration of radiocontrast agent and hydration (1mg/kg/hN/saline for 12h pre- and post-contrast, n=79), or hydration alone (1mg/kg/hN/saline for 12h pre- and post-contrast, n=80). CIN occurred in 6 of 80 patients (7.5%) in the control group and no subjects in the allopurinol group (p=0.013). In the allopurinol group, median serum creatinine concentration decreased significantly from 1.43 mg/dL [1.1-4.15 mg/dL] to 1.35 mg/dL [0.7-4.15 mg/dl] at 48 h and to 1.27 mg/dL [0.66-4.37 mg/dL] at 4 days after radiocontrast administration (p<0.0001 and p<0.0001 compared with baseline, respectively). In the control group, median serum creatinine concentration decreased non-significantly from 1.48 mg/dL [1.1-2.96 mg/dL] t...Continue Reading

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Citations

Oct 13, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Carlos Roncal-JimenezRichard J Johnson
Oct 25, 2016·International Journal of Cardiology·Tian ZuoLiheng Guo
Mar 24, 2016·Angiology·Mehmet Ali MendiMehmet Kanbay
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Apr 24, 2016·Angiology·Mehmet KanbayAdrian Covic
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Dec 23, 2019·Kidney & Blood Pressure Research·Gamze AslanMehmet Kanbay

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