Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy.

Malaria Journal
Wilfred F MbachamBrian Greenwood

Abstract

The efficacy of amodiaquine (AQ), sulphadoxine-pyrimethamine (SP) and the combination of SP+AQ in the treatment of Cameroonian children with clinical malaria was investigated. The prevalence of molecular markers for resistance to these drugs was studied to set the baseline for surveillance of their evolution with time. Seven hundred and sixty children aged 6-59 months with uncomplicated falciparum malaria were studied in three ecologically different regions of Cameroon - Mutengene (littoral equatorial forest), Yaoundé (forest-savannah mosaic) and Garoua (guinea-savannah). Study children were randomized to receive either AQ, SP or the combination AQ+SP. Clinical outcome was classified according to WHO criteria, as either early treatment failure (ETF), late clinical failure (LCF), late parasitological failure (LPF) or adequate clinical and parasitological response (ACPR). The occurrence of mutations in pfcrt, pfmdr1, dhfr and dhps genes was studied by either RFLP or dot blot techniques and the prevalence of these mutations related to parasitological and therapeutic failures. After correction for the occurrence of re-infection by PCR, ACPRs on day 28 for AQ, SP and AQ+SP were 71.2%, 70.1% and 80.9%, in Garoua, 79.2%, 62.5%, and 81...Continue Reading

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Citations

Aug 27, 2011·Malaria Journal·Mahamadou DiakiteLisa C Ranford-Cartwright
Nov 10, 2013·PloS One·Myriam GharbiUNKNOWN Members of the French National Reference Center for Imported Malaria Study
Oct 5, 2013·The Journal of Antimicrobial Chemotherapy·Huguette Gaelle Ngassa Mbenda, Aparup Das
Aug 12, 2015·The American Journal of Tropical Medicine and Hygiene·Liwang CuiPhilip J Rosenthal
Nov 17, 2019·International Journal of Molecular Sciences·Rita CapelaFrancisca Lopes
Oct 28, 2019·Parasites & Vectors·Christophe Antonio-NkondjioCharles S Wondji

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Methods Mentioned

BETA
PCR
electrophoresis
genotyping
dot blot

Clinical Trials Mentioned

NCT00146718

Software Mentioned

Exploratory Data Analysis ( EDA
Microsoft Access

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