Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential

Cancer
H KonnoS Baba

Abstract

The summation of gene mutations increases the metastatic potential of colorectal cancer. The genetic characterization and hepatic metastatic potential of five xenotransplanted human colon carcinoma strains were investigated. Furthermore, the therapeutic effect of the angiogenesis inhibitor, TNP-470, was evaluated. The correlation between gene mutation and rate of hepatic metastases of five colon cancer strains transplanted orthotopically or subcutaneously was evaluated. The strain with the highest hepatic metastatic rate from orthotopical tumors, TK-4, was used in the experiment with TNP-470 treatment. Mice were given tumor transplants orthotopically or subcutaneously followed by 30 mg/kg of TNP-470 on alternate days from Day 10 or Day 21 after transplantation, respectively. The rate of hepatic metastases from orthotopically transplanted tumors of 5 strains was 38 to 79%. Interestingly, TK-4 with K-ras and p53 mutations and overexpression of p53 protein induced hepatic metastases from both orthotopical (79%) and subcutaneous tumors (44%). Although TNP-470 only significantly inhibited subcutaneous tumor growth, its antimetastatic effect was significantly demonstrated on the hepatic metastases of both orthotopical and subcutaneou...Continue Reading

References

May 1, 1976·Scientific American·J Folkman
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Feb 14, 1991·Biochemical and Biophysical Research Communications·M KusakaJ Folkman
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·X Y FuR M Hoffman
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Jan 1, 1986·Annual Review of Biochemistry·L A LiottaU M Wewer
Apr 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H IgarashiI Kino
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·F ItohA Yachi

❮ Previous
Next ❯

Citations

Jun 20, 2012·Nanomedicine·Dipanjan PanGregory M Lanza
May 21, 2010·Future Medicinal Chemistry·Dipanjan PanGregory M Lanza
May 26, 2006·Antimicrobial Agents and Chemotherapy·Peter J DidierE S Didier
Mar 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrick M WinterGregory M Lanza
Aug 14, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne H SchmiederGregory M Lanza
Sep 1, 2010·Expert Opinion on Drug Discovery·Robert M Hoffman
Apr 2, 1999·International Journal of Oral and Maxillofacial Surgery·K MatsumotoT Tomioka
Jul 10, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Gregory M LanzaSamuel A Wickline
Nov 11, 1999·Medizinische Klinik·D SchieferA Engert
Aug 6, 2000·British Journal of Haematology·M MinischettiA F Dammacco
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael J MorowitzSuzanne Shusterman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Related Papers

The Journal of Pharmacology and Experimental Therapeutics
Ernest BrahnMona L Banquerigo
International Journal of Green Nanotechnology. Biomedicine
Kavita K KattiRaghuraman Kannan
© 2021 Meta ULC. All rights reserved