Efficacy of an Anti-transferrin Receptor 1 Antibody Against AIDS-related Non-Hodgkin Lymphoma: A Brief Communication

Journal of Immunotherapy
Tracy R Daniels-WellsManuel L Penichet

Abstract

The transferrin receptor 1 (TfR1), also known as CD71, is a target for antibody-based cancer immunotherapy due to its high expression on the surface of cancer cells and its ability to internalize. We have previously developed a mouse/human chimeric IgG3 specific for human TfR1 genetically fused to avidin, as a vector to deliver biotinylated anticancer agents into malignant cells. However, we found that this fusion protein (ch128.1Av), and to a lesser extent the same antibody without avidin (ch128.1), exhibits direct cytotoxic activity in vitro against certain malignant hematopoietic cells through the induction of TfR1 degradation and lethal iron starvation. Importantly, both ch128.1 and ch128.1Av have also shown significant anticancer activity in 2 xenograft models of the B-cell malignancy multiple myeloma. It is interesting to note that ch128.1 exhibited superior anticancer activity in both models compared with ch128.1Av, even against malignant cells that show no sensitivity to ch128.1 in vitro. In the present study, we evaluated the efficacy of ch128.1 against an AIDS-related human Burkitt lymphoma cell line (2F7) to determine if ch128.1 can eliminate these cells in vitro and in an in vivo model of AIDS-related non-Hodgkin ly...Continue Reading

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Citations

Jul 5, 2016·Immunotherapy·Tracy R Daniels-Wells, Manuel L Penichet
Apr 15, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lai Sum LeohManuel L Penichet
Jan 18, 2019·Cancer Gene Therapy·Xiaofeng XuHuaijun Zhou
Apr 6, 2021·Frontiers in Immunology·Pierre V CandelariaTracy R Daniels-Wells

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Methods Mentioned

BETA
FCS
flow cytometry

Software Mentioned

GraphPad
FCS Express
GraphPad Prism

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