Abstract
This study was undertaken to study the efficacy of praziquantel (PZQ) in potentially tolerized Schistosoma mansoni infected, egg-injected C57BL/6 mice, receiving multiple administrations of soluble egg antigen (SEA) intravenously (i.v.). Four animal groups were studied. Experimental group I received four injections of SEA (10 micrograms) intravenously on days -7, -5, -3 and -2 before infection and PZQ orally (500 mg/kg over two consecutive days 7 weeks post-infection. Three control groups received the following treatment: group II received the same tolerizing dose of SEA without PZQ, group III received PZQ in the same dose and at the same timing. Group IV received S. mansoni infection and egg injection 8 weeks post-infection and served as an infected, egg-injected control. Egg injection was conducted 8 weeks post-infection using viable S. mansoni eggs via the tail vein. Animals were killed 16 days post-egg injection, i.e. 10 weeks post-infection. After sacrifice, lungs and livers were removed for histopathological study and measurement of granuloma diameters. Spleens and serum were collected for the assay of lymphoproliferative response to SEA and antischistosomal immunoglobulins. The worm and egg burdens were also studied. Com...Continue Reading
References
May 7, 1976·Analytical Biochemistry·M M Bradford
Jan 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E Butterworth
Dec 1, 1991·Parasitology·A E ButterworthD Koech
Aug 1, 1990·Experimental Parasitology·P J Brindley, A Sher
Oct 1, 1986·Parasitology·W Harnett, J R Kusel
May 1, 1989·Molecular and Biochemical Parasitology·P J BrindleyA Sher
Jan 1, 1989·Immunopharmacology and Immunotoxicology·S S BotrosA el-Garem
Mar 22, 1986·Lancet·A C SleighJ T da França Silva
Jun 1, 1986·Experimental Parasitology·A A SabahM J Doenhoff
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J PearceA Sher
Oct 1, 1988·Experimental and Molecular Pathology·N M el-BadrawyD Herbage
May 1, 1986·Cellular Immunology·T L McCurleyD G Colley
Dec 1, 1985·Experimental Parasitology·A A SabahM J Doenhoff
Apr 1, 1986·Experimental Parasitology·W Harnett, J R Kusel
Sep 1, 1970·The Journal of Experimental Medicine·D L Boros, K S Warren
Dec 1, 1984·Experimental Parasitology·A P Norden, M Strand
Apr 1, 1983·Medicinal Research Reviews·P AndrewsJ Seubert
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·S S BotrosM T Khayyal
Aug 17, 1995·Nature·T A WynnA Sher
Apr 1, 1995·International Journal of Immunopharmacology·S S BotrosD A Dean
Jan 1, 1987·Parasitology Today·A E ButterworthA Sher
May 1, 1988·Parasitology Today·W Harnett
Oct 1, 1992·Parasitology Today·T A DayR A Pax
Citations
Nov 25, 2000·International Journal of Immunopharmacology·S S BotrosH I Hassanein
Aug 20, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sanaa S BotrosRobert Bergquist
Jun 24, 2015·Veterinary Parasitology·Germanus S BahBenjamin L Makepeace
Dec 10, 2002·Memórias do Instituto Oswaldo Cruz·Allen W CheeverZilton A Andrade