PMID: 9172014Dec 1, 1996Paper

Efficacy of an antipathology vaccine in murine schistosomiasis administered with and without chemotherapy

International Journal of Immunopharmacology
S S BotrosH I Hassanein

Abstract

This study was undertaken to study the efficacy of praziquantel (PZQ) in potentially tolerized Schistosoma mansoni infected, egg-injected C57BL/6 mice, receiving multiple administrations of soluble egg antigen (SEA) intravenously (i.v.). Four animal groups were studied. Experimental group I received four injections of SEA (10 micrograms) intravenously on days -7, -5, -3 and -2 before infection and PZQ orally (500 mg/kg over two consecutive days 7 weeks post-infection. Three control groups received the following treatment: group II received the same tolerizing dose of SEA without PZQ, group III received PZQ in the same dose and at the same timing. Group IV received S. mansoni infection and egg injection 8 weeks post-infection and served as an infected, egg-injected control. Egg injection was conducted 8 weeks post-infection using viable S. mansoni eggs via the tail vein. Animals were killed 16 days post-egg injection, i.e. 10 weeks post-infection. After sacrifice, lungs and livers were removed for histopathological study and measurement of granuloma diameters. Spleens and serum were collected for the assay of lymphoproliferative response to SEA and antischistosomal immunoglobulins. The worm and egg burdens were also studied. Com...Continue Reading

References

Jan 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E Butterworth
Aug 1, 1990·Experimental Parasitology·P J Brindley, A Sher
Jun 1, 1986·Experimental Parasitology·A A SabahM J Doenhoff
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J PearceA Sher
Oct 1, 1988·Experimental and Molecular Pathology·N M el-BadrawyD Herbage
May 1, 1986·Cellular Immunology·T L McCurleyD G Colley
Dec 1, 1985·Experimental Parasitology·A A SabahM J Doenhoff
Apr 1, 1986·Experimental Parasitology·W Harnett, J R Kusel
Apr 1, 1983·Medicinal Research Reviews·P AndrewsJ Seubert
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·S S BotrosM T Khayyal
Jan 1, 1987·Parasitology Today·A E ButterworthA Sher
May 1, 1988·Parasitology Today·W Harnett
Oct 1, 1992·Parasitology Today·T A DayR A Pax

❮ Previous
Next ❯

Citations

Aug 20, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sanaa S BotrosRobert Bergquist
Dec 10, 2002·Memórias do Instituto Oswaldo Cruz·Allen W CheeverZilton A Andrade

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.