PMID: 9653476Jul 8, 1998Paper

Efficacy of an aqueous and a powder formulation of nasal budesonide compared in patients with nasal polyps

American Journal of Rhinology
M TosT Tvermosegaard

Abstract

Nasal polyps are commonly treated surgically. Intranasal administration of topical corticosteroids has gained increased acceptance as a treatment alternative. The aim of our study was to compare the efficacy of treatment of two formulations of budesonide with placebo on nasal polyps. At four Danish clinics 138 patients suffering from moderate or severe nasal polyps were randomized to a twice daily treatment with Rhinocort Aqua 128 micrograms, Rhinocort Turbuhaler 140 micrograms or placebo (Astra Draco, Sweden) for 6 weeks. Polyp size (primary efficacy variable), nasal symptoms, sense of smell, and patients' overall evaluation of treatment of efficacy were assessed by scores. Polyp size was reduced significantly in both budesonide treated groups compared with placebo, but there was no statistical difference between the two actively treated groups. Patients' nasal symptom scores was significantly more reduced in the Aqua compared to the Turbuhaler treated group, and both reduced symptom scores were significantly better compared to placebo. Sense of smell was significantly improved in the actively treated groups compared to placebo. The proportion of patients rating substantial or total control over symptoms after 6 weeks treatmen...Continue Reading

References

Jan 1, 1990·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·H Stammberger, W Posawetz
Dec 1, 1990·The Journal of Allergy and Clinical Immunology·J RuhnoJ Dolovich
Feb 1, 1988·The Journal of Laryngology and Otology·S HartwigN Lindqvist
Aug 1, 1984·The Journal of Laryngology and Otology·A B Drake-LeeA Grace
Feb 1, 1995·Clinical Otolaryngology and Allied Sciences·T LildholdtN Lindqvist
Sep 1, 1994·Acta Oto-laryngologica·K Larsen, M Tos
Jun 1, 1996·Clinical Otolaryngology and Allied Sciences·A Drake-Lee
Dec 1, 1993·Clinical Otolaryngology and Allied Sciences·L Vendelo JohansenB Synnerstad

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Citations

Sep 7, 2007·HNO·B A StuckUNKNOWN German Society for Otorhinolaryngology, Head and Neck Surgery
Dec 6, 2011·HNO·B A StuckUNKNOWN German Society of Otorhinolaryngology, Head and Neck Surgery
Apr 18, 2008·Current Allergy and Asthma Reports·Umur Hatipoğlu, Israel Rubinstein
Jan 26, 2012·Current Allergy and Asthma Reports·Isam Alobid, Joaquim Mullol
Apr 14, 2007·Current Infectious Disease Reports·Umur Hatipo, Israel Rubinstein
Jul 1, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Seth J KanowitzMartin J Citardi
Aug 30, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Stephanie A JoeJie Huang
Jun 11, 2004·Clinical Therapeutics·Brett E Stanaland
Aug 21, 2003·Auris, Nasus, Larynx·Ulku TuncerCagatay Akcali
Mar 16, 2007·The Journal of Laryngology and Otology·E McNeillS Carrie
Jan 2, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Alice Huang, Satish Govindaraj
Feb 25, 2011·International Archives of Allergy and Immunology·Claus Bachert
Jun 21, 2013·International Journal of General Medicine·Patorn PiromchaiSanguansak Thanaviratananich
Mar 12, 2003·PharmacoEconomics·Fredrik Berggren, Leif Johansson
Mar 4, 2006·Treatments in Respiratory Medicine·Niels Mygind, Valerie Lund
Dec 13, 2012·American Journal of Rhinology & Allergy·Virat KirtsreesakulSuwalee Ruttanaphol
Aug 2, 2012·Allergy & Rhinology·Lee C YoungRichard G Douglas
Jan 15, 2013·Drug Delivery and Translational Research·Per Gisle Djupesland
Aug 2, 2007·Current Medical Research and Opinion·William StormsLeonard Fromer
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Apr 15, 2011·Mayo Clinic Proceedings·Eli O Meltzer, Daniel L Hamilos
May 11, 2010·The Journal of Allergy and Clinical Immunology·Thibaut Van ZeleClaus Bachert
Feb 1, 2008·The Journal of Allergy and Clinical Immunology·Catherine Butkus SmallAngela Damiano
Mar 14, 2012·The Laryngoscope·Luke RudmikZachary M Soler
Apr 5, 2013·The Laryngoscope·Calvin C WeiNoam A Cohen
Feb 15, 2012·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·S I VentoH Malmberg
Aug 2, 2005·Immunology and Allergy Clinics of North America·P van CauwenbergeC Bachert
Jun 8, 2013·Brazilian Journal of Otorhinolaryngology·João Ferreira de MelloRoberto Eustáquio Santos Guimarães
Nov 18, 2014·International Forum of Allergy & Rhinology·Sarfaraz M BanglawalaRodney J Schlosser
Apr 25, 2000·Acta Oto-laryngologica·L JohanssonM Bende
Aug 28, 2014·The Journal of Allergy and Clinical Immunology·Javier MilaraJulio Cortijo
Apr 27, 2016·The Cochrane Database of Systematic Reviews·Lee Yee ChongAnne G M Schilder
Apr 27, 2016·The Cochrane Database of Systematic Reviews·Lee Yee ChongMartin J Burton
Oct 4, 2011·Allergy, Asthma & Immunology Research·Harsha H Kariyawasam, Glenis K Scadding
Jun 9, 2005·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Jan Gosepath, Wolf J Mann
Apr 17, 2019·American Journal of Rhinology & Allergy·Kristin A SeiberlingChristopher A Church
May 1, 2019·American Journal of Rhinology & Allergy·Neal DeotEdward D McCoul
Jun 1, 2016·Current Otorhinolaryngology Reports·David A Gudis, Zachary M Soler
Jul 28, 2010·Expert Review of Respiratory Medicine·José Maria GuilemanyJoaquim Mullol
Apr 26, 2016·The Cochrane Database of Systematic Reviews·Larry KalishRichard J Harvey
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou

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