PMID: 16113891Aug 23, 2005Paper

Efficacy of an enzyme-linked immunosorbent assay as a diagnostic tool for schistosomiasis mansoni in individuals with low worm burden

Memórias do Instituto Oswaldo Cruz
Edward José de OliveiraDirce Mary Correia Lima


IgM-ELISA is an immunoenzymatic method useful for detection of IgM antibodies against a fraction of Schistosoma mansoni adult worm antigen (AWA) that is soluble in trichloroacetic acid (AWA-TCA). This method was applied to three groups of individuals with different clinical and epidemiological characteristics, and the results compared with those obtained by other diagnostic methods: immunofluorescence test for detection of IgM antibodies (IgM-IFT) or IgG antibodies (IgG-IFT), ELISA for detection of IgG antibodies (IgG-ELISA), and two parasitological methods, Kato-Katz and miracidium hatching. The IgM-ELISA presented a sensitivity of 98%, when the parasitologic fecal examination was defined as reference diagnostic method, and a specificity of 98 and 97.3%, respectively for the group of clinically healthy individuals and other helminth carriers. A comparative analysis between the results of IgM-ELISA and those obtained by other serologic tests showed a good degree of agreement, with Kappa indices ranging from 0.95 to 0.98. The diagnostic efficacy of 97.8%, as determined with schistosomiasis patients with low parasitic burden, suggests the excellent performance of the IgM-ELISA and its usefulness for the diagnosis of schistosomias...Continue Reading


Jan 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffJ Bain
Apr 1, 1996·The American Journal of Tropical Medicine and Hygiene·D EngelsB Gryseels
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Jul 16, 2002·Memórias do Instituto Oswaldo Cruz·Herminia Yohko KanamuraLuiz Candido de Souza Dias
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Aug 1, 1992·Parasitology Today·S J de Vlas, B Gryseels

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