Efficacy of an executive function intervention programme in MS: a placebo-controlled and pseudo-randomized trial

Multiple Sclerosis : Clinical and Laboratory Research
Frauke FinkHelmut Hildebrandt

Abstract

We evaluated a rehabilitation programme for executive deficits in multiple sclerosis patients by comparing outcome scores of a cognitive intervention group (CIG; n = 11) with those of a placebo group (n = 14) and an untreated group (n = 15). Executive functioning and verbal learning improved significantly more in the CIG. The treatment effect on verbal learning was still present at 1-year follow-up. Baseline brain atrophy, quantified by the brain parenchymal fraction, was associated with treatment effects for one aspect of executive functioning. Consequently, cognitive intervention may be beneficial and baseline brain atrophy has some predictive value in determining treatment outcome for executive functioning.

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Citations

Nov 28, 2012·Journal of Neurology·Maria Pia AmatoGiancarlo Comi
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