Efficacy of an interleukin-1β receptor antagonist (anakinra) in idiopathic recurrent pericarditis.

Pediatric Cardiology
Alessandra ScardapaneLuciana Breda

Abstract

Pericarditis may recur in up to 30 % of adult patients, but recurrent pericarditis is a rare disease in childhood. The etiology of the initial attack and the causes of recurrences often remain unknown. Recurrent pericarditis is accompanied by a high morbidity rate and may represent a challenge to the clinician due to problems in management. Therapeutic strategies are not specific and include nonsteroidal antiinflammatory drugs, corticosteroids, immunosuppressive drugs, colchicine, and pericardiectomy. Controlled trials have demonstrated that colchicine can reduce the recurrent rate of pericarditis, whereas early corticosteroid therapy promotes recurrences. Anakinra, a recombinant human interleukin-1β receptor antagonist, is a promising new biologic agent for the treatment of autoinflammatory diseases such as cryopyrinopathies, tumor necrosis factor receptor-associated periodic syndrome, and hyperimmunoglobulinemia D with periodic fever syndrome. This report describes an 11-year-old boy successfully treated with anakinra for a steroid-dependent recurrent pericarditis unresponsive to conventional treatment.

References

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Citations

Mar 7, 2013·Pediatric Cardiology·Marisol Camacho-Lovillo, Ana Méndez-Santos
Nov 28, 2013·Seminars in Immunology·Charles A Dinarello, Jos W M van der Meer
Mar 5, 2016·Cardiology Research and Practice·Shankar BaskarAndrew Zeft
Jun 22, 2017·European Heart Journal. Cardiovascular Pharmacotherapy·Leo F BuckleyAntonio Abbate
Nov 13, 2018·Journal of Cellular Physiology·Aldo Bonaventura, Fabrizio Montecucco
Dec 31, 2014·Molecular Medicine·Charles Anthony Dinarello
Dec 5, 2018·Cardiology in the Young·Moises Rodriguez-GonzalezAna Castellano-Martinez
Nov 12, 2019·Expert Review of Cardiovascular Therapy·Alessandro AndreisGaetano Maria de Ferrari
Apr 17, 2016·Archives of Disease in Childhood·Samer AlabedAmanda Burls
Jan 26, 2016·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler
Oct 18, 2019·Yeungnam University Journal of Medicine·Ju Hee ShinHee Joung Choi
Apr 9, 2020·Journal of Cardiovascular Pharmacology·Eduardo Thadeu de Oliveira CorreiaEvandro Tinoco Mesquita
Sep 25, 2017·Rheumatology International·Sharika Gopakumar Menon, Petros Efthimiou
Mar 21, 2016·Current Cardiology Reports·James GentryChristine L Jellis
Apr 11, 2018·Internal and Emergency Medicine·Antonio BrucatoDomenico Prisco
Jan 1, 2018·Current Otorhinolaryngology Reports·Charles A Dinarello
Mar 6, 2021·JACC. Basic to Translational Science·Adolfo G MauroStefano Toldo
Mar 13, 2021·Frontiers in Pharmacology·Hana MalcovaRudolf Horvath
May 8, 2020·Trends in Cardiovascular Medicine·Giuseppe LopalcoFlorenzo Iannone
Oct 8, 2014·Pediatrics·M Rosa del FresnoJaime de Inocencio

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