Efficacy of Antibiotic Agents after Spill of Bile and Gallstones during Laparoscopic Cholecystectomy

Surgical Infections
Aafke H van DijkMarja A Boermeester

Abstract

Background: Perforation of the gallbladder during laparoscopic cholecystectomy (LC) results in spill of bile or gallstones in the abdominal cavity. The aim of this study was to assess whether antibiotic agents after spill have an effect on post-operative and infectious complications. Patients and Methods: Operative reports and clinical data of patients undergoing LC between 2012 and 2016 in three hospitals were screened retrospectively for spill of bile and spill of gallstones. Included patients were divided into two groups: Patients who were treated with antibiotic agents (either prophylactic or a single administration during or directly post-operatively because of spill) and patients who did not receive any antibiotic agents. Patients were also categorized as to uncomplicated or complicated gallstone disease. Multi-variable logistic regression was used to assess risk factors for overall and infectious complications after spill. Results: Spill was reported in 14.7% (481 of 3,262). The infectious complication rate was 8.7% (42/481). Of 481 patients, 295 (61.3%) had uncomplicated gallstone disease and 239 (49.7%) received antibiotic treatment. Rates of infectious complications were comparable among patients receiving antibi...Continue Reading

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Citations

Jul 1, 2020·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Zülfikar KarabulutHasan Çaliş
Nov 18, 2020·ANZ Journal of Surgery·Jing-Zhao HanYan-Hui Peng
Jun 20, 2021·Asian Journal of Endoscopic Surgery·Masashi TsunematsuSatoshi Ishiyama

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Methods Mentioned

BETA
lavage

Software Mentioned

SPSS

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