Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial

The British Journal of Oral & Maxillofacial Surgery
P XueR Hou

Abstract

We investigated the effect of antibiotic prophylaxis on postoperative inflammatory complications after operations for impacted mandibular third molars in Chinese patients. A total of 207 patients had their bilateral third molars removed in a split-mouth, double-blind, self-controlled, clinical trial in two visits. For one side amoxicillin (or clindamycin) was given (antibiotic group) from one hour before operation until 3 days postoperatively. For the other side a placebo was given (placebo group) at the same time. The outcome, including alveolar osteitis, surgical wound infection, prebuccal infection, and infection of the anterior isthmus of fauces, was assessed 2 and 10 days postoperatively. A total of 192 patients completed the study, and there was no difference between the groups in the incidence of inflammatory complications. In the treatment group, there were 4 cases of alveolar osteitis (2%), 2 infections of the wound (1%), and 14 other reactions (gastrointestinal (n=4), bleeding (n=2), ulcer (n=2), and fever (n=6)). In the placebo group, there were 6 cases of alveolar osteitis (3%), 2 wound infections (1%), and 22 other reactions (bleeding (n=6), ulcer (n=2) and fever (n=14)). There was no significant difference in the ...Continue Reading

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Citations

Dec 27, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Karoline Brørup MarcussenElse Marie Pinholt
Sep 12, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Carolin GötzAndreas Kolk
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Aug 9, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Eva RamosIcíar Arteagoitia
Mar 15, 2018·Oral and Maxillofacial Surgery·Carllini Barroso VicentiniRogério Heládio Lopes Motta
May 6, 2019·Antibiotics·Gabriele CervinoLuca Fiorillo
Jan 10, 2021·International Journal of Environmental Research and Public Health·Aleksandra JarońGrzegorz Trybek
Nov 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Maria Del Mar Mariscal-CazallaMaria Victoria Olmedo-Gaya
Feb 25, 2021·The Cochrane Database of Systematic Reviews·Giovanni LodiMaddalena Manfredi
May 22, 2021·The British Journal of Oral & Maxillofacial Surgery·T MilicD Gebauer
Jun 8, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Simra Azher, Amish Patel
Jul 3, 2021·International Journal of Dentistry·Elaine Kueh Yue YiRohit Kunnath Menon
Oct 10, 2021·Journal of Oral Rehabilitation·Anna GhoshRichard Moore

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