Efficacy of antiepileptic drugs in autoimmune epilepsy: A systematic review

Seizure : the Journal of the British Epilepsy Association
Pablo Cabezudo-GarcíaPedro J Serrano-Castro

Abstract

Review the evidence of the efficacy of AEDs (antiepileptic drugs) in autoimmune epilepsy. Literature research on Medline and Embase was carried out through January 2018. We included MeSH terms, free text and terms related to "autoimmune epilepsy", "autoimmune encephalitis", "limbic encephalitis", "autoimmune seizures", "antiepileptic drug", "seizure treatment", and "epilepsy treatment". The research was carried out by two reviewers who independently examined titles, abstracts and selection criteria. The main outcome was AED efficacy. Results regarding types of AEDs and autoantibody presence and type in responding patients were considered secondary endpoints. Quality of evidence was analysed by reading the whole text and following Scottish Intercollegiate Guidelines Network (SIGN) guidelines. After an initial selection of 1656 articles, only six retrospective observational studies with a level of evidence between 2+ and 3 and a SIGN B recommendation degree remained. The total number of patients examined was 139. The estimated efficacy of AEDs with AE was 10.7%. There was response to AEDs in 18% of seronegative patients, 11% in VGKC positives and in 8% with GAD65. Seventy-three percent of responders to AEDs were in treatment with...Continue Reading

Citations

Jul 10, 2019·Epilepsia·Alberto VogrigJérome Honnorat
May 22, 2020·SN Comprehensive Clinical Medicine·Lucille BrunkerJoseph J Schlesinger
May 14, 2020·Epilepsia·Robb WesselinghMastura Monif
Feb 23, 2020·Journal of Neuroimmunology·Xinxin LiSongyan Liu
Jan 20, 2021·Current Opinion in Neurology·Christian G Bien
Apr 4, 2021·Brain Sciences·Pablo Cabezudo-GarcíaPedro J Serrano-Castro
Jun 9, 2020·Seizure : the Journal of the British Epilepsy Association·Etsegenet TizazuEric Lancaster
Oct 8, 2021·Seminars in Neurology·Abrar O Al-FarajTrudy D Pang

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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