Efficacy of antimicrobial coated orthopaedic implants on the prevention of periprosthetic infections: a systematic review and meta-analysis

Journal of Bone and Joint Infection
Olga D SavvidouPanayiotis J Papagelopoulos

Abstract

Introduction: Implant-associated infections are a major problem in orthopaedic surgery. Local delivery systems of antimicrobial agents on the implant surface have attracted great interest recently. The purpose of this study was to identify antimicrobial coatings currently used in clinical practice, examining their safety and effectiveness in reducing post-operative infection rates. Materials and Methods: A systematic review was conducted in four databases (Medline, Embase, Cochrane, Cinahl) according to the Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) guidelines up to December 2019, using the key words "orthopaedic implant coated", "coated implant infection", "silver coating " and "antibiotic coating". Results: Seven articles involving 1307 patients (561 with coated implants and 746 controls who were not) comparing the incidence of periprosthetic infections after the application of internal fracture fixation, total arthroplasties and endoprostheses were evaluated. Three different coating technologies were identified: gentamicin coating for tibia nail and total arthroplasties; silver technology and povidone-iodine coating for tumour endoprostheses and titanium implants. Meta-analysis demonstrated t...Continue Reading

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Citations

Sep 17, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maxim ShevtsovMark Pitkin
Jan 7, 2021·Biomedicines·Victoria WallPhong A Tran

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Methods Mentioned

BETA
total arthroplasties
total hip arthroplasties
amputation

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Excel
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MedCalc Meta - analysis
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