PMID: 8970215Dec 1, 1996Paper

Efficacy of antimicrobial prophylaxis for recurrent middle ear effusion

The Pediatric Infectious Disease Journal
E M MandelM Kurs-Lasky

Abstract

This trial compared the efficacy of amoxicillin prophylaxis with that of placebo for the management of recurrent middle ear effusion (MEE) in children. Children between 7 months and 12 years of age who were effusion-free at entry but had histories of chronic or recurrent MEE were randomly assigned to receive either amoxicillin (20 mg/kg once daily) or placebo for 1 year. They were examined monthly and when there were symptoms of ear, nose or throat disease. Acute otitis media (AOM) and new episodes of otitis media with effusion (OME) were treated with amoxicillin-clavulanate; tympanocentesis was performed when possible for episodes of AOM. Throat cultures were obtained at entry; 4, 8 and 12 months after entry; and with new episodes of AOM and OME. Tympanometry was performed at each visit and audiometry was performed at entry and 4, 8 and 12 months after entry. One hundred eleven children were entered in this study. The rates per person year of new episodes of disease in the amoxicillin and placebo groups, respectively, were: MEE, 1.81 vs. 3.18 (P < 0.001); AOM, 0.28 vs. 1.04 (P < 0.001); and OME, 1.53 vs. 2.15 (P = 0.016). Subjects in the amoxicillin group had less time with MEE than the placebo group (19.7 and 33.2%, respectiv...Continue Reading

References

Apr 1, 1992·The Pediatric Infectious Disease Journal·E M MandelR J Nozza
Jun 1, 1985·American Journal of Diseases of Children·I VarsanoF Mimouni
Aug 1, 1982·Archives of Disease in Childhood·R H SchwartzW J Rodriguez
Sep 1, 1993·The Pediatric Infectious Disease Journal·E M MandelH E Rockette

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Citations

May 23, 2000·The Pediatric Infectious Disease Journal·J O Klein
Jul 17, 2003·Pediatric Case Reviews·Gunnar B Stickler
Oct 4, 2008·The Pediatric Infectious Disease Journal·John J AlexanderMary D Murphy
Jul 24, 2001·Archives of Disease in Childhood·C C Butler, H MacMillan
Jun 27, 2003·Primary Care·Christopher J Harrison
Oct 21, 2006·The Cochrane Database of Systematic Reviews·A J Leach, P S Morris
Oct 2, 2003·The Laryngoscope·Richard M Rosenfeld, David Kay
Jun 16, 2017·Current Otorhinolaryngology Reports·Anna Granath
Oct 1, 1999·Paediatrics & Child Health

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