PMID: 8955454Nov 1, 1996Paper

Efficacy of antimicrobial treatment in non-dysenteric persistent diarrhoea in a community setting

Acta Paediatrica
R BahlA Bagati

Abstract

To determine the efficacy of antimicrobial treatment in non-dysenteric persistent diarrhoea in a community setting. In this double-blind field trial, 156 children aged 4-36 months with persistent diarrhoea not associated with Giardia lamblia infestation seeking treatment in a community outpatient clinic, were randomized to receive a combination of nalidixic acid and metronidazole, metronidazole alone, or placebo for 7 days. In comparison with placebo, metronidazole treatment did not result in a significant reduction in the mean post-enrollment diarrhoeal duration and stool frequency, increase in the proportion of patients recovered by days 3, 5 and 7 of treatment, and increase in weight gain at days 7 and 14. Comparing the combination of nalidixic acid and metronidazole with metronidazole alone, 17.5% more children treated with the combination recovered by day 3 of treatment (p = 0.08) and the mean stool frequency ascertained on day 7 for the previous 24 h was 26.8% less in them (p = 0.05). The weight gains at days 7 and 14 were similar in the two groups. These findings indicate that metronidazole offers no therapeutic benefit in persistent diarrhoea not associated with Giardia lamblia and nalidixic acid has only a modest clini...Continue Reading

References

Aug 1, 1992·Journal of Pediatric Gastroenterology and Nutrition·S BhatnagarD K Kashyap
Sep 1, 1992·Acta Paediatrica. Supplement·A V BartlettJ R Cruz
Sep 1, 1992·Acta Paediatrica. Supplement·F J HenryK M Aziz
Apr 1, 1974·Archives of Disease in Childhood·D N ChallacombeC M Anderson
May 1, 1983·Archives of Disease in Childhood·I D HillM D Bowie
Sep 1, 1993·The Pediatric Infectious Disease Journal·R E Black

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Citations

Oct 5, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·John L KitzmillerSaiyin Kwan
Feb 9, 2008·Annual Review of Plant Biology·Matthew J PaulYuhua Zhang

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