Efficacy of Antiviral Therapy in HBsAg-Positive Pregnant Women to Reduce Mother-to-Infant Transmission of Hepatitis B Virus

Journal of Obstetrics and Gynaecology of India
Jyoti Ramesh Chandran, Sajala Vimal Raj

Abstract

Hepatitis B is a major health concern in Asia. Chronic hepatitis B virus (HBV) infection may cause hepatic cirrhosis and liver cancer. HBV is transmitted horizontally through blood and blood products and vertically from mother to infant. Perinatal infection is the main route of transmission in regions with high prevalence of hepatitis B surface antigen (HbsAg) carriage, and perinatal transmission leads to high rates of chronic infection. Therefore, it is important to prevent mother-to-child transmission (MTCT) of HBV1. The present study aims at comparing the use of antivirals (lamivudine vs tenofovir) in reducing MTCT. A total of 60 HbsAg-positive pregnant women were enrolled in the prospective study to test the efficacy of antiviral (lamivudine vs tenofovir-category B drug) to reduce mother-to-child transmission and monitor hepatitis B viral status in infant. HbsAg-positive pregnant women aged 18-43 years at gestational age between 28 and 32 weeks were followed up. They were tested for HBsAg, liver function test and HBeAg. In whom HbeAg was positive, HBV viral load was tested. Sixty patients with high viral load (>6 log copies/ml) were recruited in the study. Alternate patients were randomized into two groups. Group A comprise...Continue Reading

References

Dec 5, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Miltiadis A PapadakisAris Antsaklis
May 6, 2009·The Medical Journal of Australia·Elke WisemanMiriam T Levy
Sep 19, 2014·World Journal of Gastroenterology : WJG·Zhao ZhangXiao-Min Xiao
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultUNKNOWN American Association for the Study of Liver Diseases
Jun 16, 2016·The New England Journal of Medicine·Calvin Q PanUNKNOWN China Study Group for the Mother-to-Child Transmission of Hepatitis B

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