Efficacy of Applying Hyaluronic Acid Gels in the Primary Prevention of Intrauterine Adhesion after Hysteroscopic Myomectomy: A Meta-Analysis of Randomized Controlled Trials

Life
Min ChengPeng-Hui Wang

Abstract

Intrauterine adhesion (IUA), which mainly occurs after intrauterine surgery or an inflammatory process, is an important but often neglected condition in women of reproductive age. The presentation of IUA varies greatly, ranging from symptom-free to severe, with amenorrhea or infertility. With much advanced development of intrauterine instruments, more intrauterine diseases can be successfully cured by hysteroscopic surgery. Among these, submucosal myoma is one of the best examples. Submucosal myomas are often related to abnormal bleeding, anemia, and possible infertility or miscarriage. However, submucosal myoma after hysteroscopic myomectomy may be complicated by IUA in various grades of severity, and its incidence and prevalence might be nearly one-quarter to one-third of patients, suggesting an urgent need for efforts to decrease the risk of developing IUA after hysteroscopic myomectomy. Many strategies have been reported to be useful for this purpose, and intrauterine application of anti-adhesive gels, such as polyethylene oxide-sodium carboxymethylcellulose (PEO-NaCMC) or auto-crosslinked hyaluronic acid (ACHA), has become increasingly popular in routine clinical practice. This meta-analysis is aimed at investigating the e...Continue Reading

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Citations

May 11, 2021·Taiwanese Journal of Obstetrics & Gynecology·Huann-Cheng HorngPeng-Hui Wang
May 11, 2021·Taiwanese Journal of Obstetrics & Gynecology·Chia-Hao LiuPeng-Hui Wang
May 11, 2021·Taiwanese Journal of Obstetrics & Gynecology·Yiu-Tai LiPeng-Hui Wang
Jun 3, 2021·International Journal of Molecular Sciences·Wen-Ling LeePeng-Hui Wang

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Methods Mentioned

BETA
biopsy

Software Mentioned

Comprehensive Meta - analysis

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