Efficacy of artemisinin-naphthoquine phosphate against Schistosoma haematobium adult flukes: dose-effect relationship and tegumental alterations.

Journal of Helminthology
Samar N El-BeshbishiAmira Taman

Abstract

Schistosoma haematobium and Schistosoma mansoni infections have broadly overlapping geographical distributions. Praziquantel is the only treatment for human schistosomiasis, so drug tolerance and/or resistance are major concerns. Artemisinin-naphthoquine phosphate (CO-ArNp), an artemisinin-based combination therapy endorsed by the World Health Organization as a gold standard therapy for malaria, has also been identified as a promising treatment for S. mansoni. In this in vitro study, we tested the effect of 1-40 μg/ml CO-ArNp on S. haematobium worms, and inspected tegumental changes by using scanning electron microscopy (SEM), aiming to determine if this combination therapy has a broad-spectrum antischistosomal activity. Incubation of S. haematobium adults with 20 or 30 μg/ml CO-ArNp caused 100% mortality of worms within 72 or 48 h, respectively. SEM examination showed extensive tegumental alterations such as oedema, constriction, shortening and loss of spines, fissuring, sloughing and perforation, resulting in exposure of the underlying basal lamina, mainly in treated male schistosomes. Besides the well-established potent efficacy, bioavailability, tolerability and safety of the antimalarial artemisinin-naphthoquine phosphate ...Continue Reading

References

Jul 1, 1967·The American Journal of Tropical Medicine and Hygiene·R H Duvall, W B DeWitt
Mar 31, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·S XiaoM Tanner
Jun 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Denis BoulangerFrancois Simondon
Mar 6, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ayoub A MohamedIshag Adam
Jul 15, 2009·PLoS Neglected Tropical Diseases·Juliana B R Corrêa SoaresMarcus F Oliveira
Aug 25, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Clive ShiffRobert W Veltri
Dec 8, 2009·Acta Tropica·Charles H King
Mar 31, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer KeiserEliézer K N'Goran
Sep 14, 2010·Experimental Parasitology·Josué de MoraesToshie Kawano
Oct 25, 2011·PLoS Neglected Tropical Diseases·Gabriel RinaldiPaul J Brindley
Feb 22, 2012·PLoS Neglected Tropical Diseases·Julien PortelaAnne Robert
Jan 1, 2007·Expert Opinion on Drug Discovery·Sith SathornsumeteeJeremy N Rich
Sep 24, 2016·The Korean Journal of Parasitology·Maysa Ahmad ErakyGehan Abd El-Rahman Rashed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.