Efficacy of Autologous Platelet Concentrates as Adjuvant Therapy to Surgical Excision in the Treatment of Keloid Scars Refractory to Conventional Treatments: A Pilot Prospective Study

Annals of Plastic Surgery
Barbara HersantJean Paul Meningaud

Abstract

After conventional treatments, keloid scars show varying degrees of recurrence. The aim of this study was to assess the efficacy and safety of platelet-rich plasma in the treatment of postoperative keloid scars refractory to conventional treatments. This pilot prospective study was conducted in 17 patients with keloid scars who did not respond to 4 injections of cortisone or radiotherapy after extralesional resection of keloid. Platelet-rich plasma was injected intraoperatively and then 3 times with a 1-month interval. The primary end point was the complete remission of keloid scars 2 years posttreatment. Scar pruritus severity was scored before and after treatment. The study protocol was approved by the ethics committee and authorized by the French National Agency. This trial was registered at ClinicalTrials.gov, identifier NCT02922972. Nine keloid scars (53%) were completely resolved at 2 years, and 5 (29%) completely relapsed after treatment. Pruritus severity score was significantly lower at 2 years compared with baseline (1.33 ± 0.97 before treatment and 0.40 ± 0.63 at 2 years, P < 0.003). The mean Vancouver Scar Scale score significantly improved (8.18 ± 2.38 before treatment and 3.82 ± 1.98 at 2 years, P < 0.001). Inject...Continue Reading

References

Nov 1, 1992·The Journal of Investigative Dermatology·M BabuN Oliver
Oct 1, 1994·The Journal of Investigative Dermatology·M HaisaG R Grotendorst
Oct 1, 1996·Plastic and Reconstructive Surgery·D A BettingerI K Cohen
Mar 12, 1998·Molecular Medicine Today·T L Tuan, L S Nichter
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Apr 16, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E Marx
Sep 15, 2004·The American Journal of Dermatopathology·Julia Yu-Yun LeeTak-Wah Wong
Sep 30, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Wei XiaGeorge P Yang
Nov 18, 2005·Lancet·Vincent Falanga
Jan 13, 2006·Plastic and Reconstructive Surgery·Ali Al-AttarSteven P Davison
Mar 10, 2009·Burns : Journal of the International Society for Burn Injuries·Janakiraman MeenakshiMary Babu
Feb 5, 2010·Archives of Dermatological Research·Barbara Shih, Ardeshir Bayat
Feb 9, 2010·Journal of Dental Research·S Guo, L A Dipietro
Aug 19, 2011·The American Journal of Sports Medicine·Emily A SundmanLisa A Fortier
Aug 23, 2011·The American Journal of Sports Medicine·Gerben M van BuulGerjo J V M van Osch
Jul 7, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ryu Yoshida, Martha M Murray
Oct 4, 2012·The Journal of Bone and Joint Surgery. American Volume·Taralyn M McCarrelLisa A Fortier
Jun 27, 2013·Journal of Oral and Maxillofacial Pathology : JOMFP·Santosh HunasgiRavikumar Shamala
Jul 10, 2013·Developmental Cognitive Neuroscience·Diane GoldenbergAdriana Galván
Oct 19, 2013·The American Journal of Sports Medicine·Stacie G BoswellLisa A Fortier
Mar 4, 2014·Clinical and Experimental Otorhinolaryngology·Seung Hoon WooSang Hyuk Lee
Apr 15, 2014·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Jeremy MagalonFlorence Sabatier
Nov 6, 2015·Frontiers in Physiology·Constanza E MartínezVerónica A Palma Alvarado
Feb 5, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Jonathan P AndrewsJouni Uitto
Jul 6, 2016·Acta Dermato-venereologica·Eveline BijlardMarc A M Mureau

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