Jul 6, 2000

Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication

Archives of Toxicology
T M Shih, John H McDonough

Abstract

The ability of the nerve agents tabun, sarin, soman, GF, VR, and VX to produce brain seizures and the effectiveness of the anticholinergics biperiden HCl or atropine SO4 as an anticonvulsant treatment were studied in a guinea-pig model. All animals were implanted a week prior to the experiment with cortical electrodes for electroencephalogram (EEG) recordings. On the day of exposure, the animals were pretreated with pyridostigmine (0.026 mg/kg, i.m.) 30 min prior to challenge with a 2 x LD50 dose (s.c.) of a given agent. In separate experiments, animals were challenged with 5 x LD50 (s.c.) of soman. One minute after agent challenge, the animals were treated intramuscularly (i.m.) with 2 mg/kg atropine SO4 admixed with 25 mg/kg 2-PAM Cl and then observed for the onset of seizure activity. Five minutes after the start of nerve agent-induced EEG seizures, animals were treated i.m. with different doses of biperiden HCl or atropine SO4 and observed for seizure termination. The anticonvulsant ED50 of biperiden HCl and atropine SO4 for termination of seizures induced by each nerve agent was calculated and compared. With equally toxic doses (2 x LD50) of these agents, continuous EEG seizures (status epilepticus) developed in all animal...Continue Reading

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Mentioned in this Paper

Anticholinergic mydriatics and cycloplegics
Electroencephalography
Anticonvulsants
Anticholinergics inhalants for obstructive airway diseases
Cavia
Soman
Biperiden Hydrochloride
Atropine
Cholinesterase Inhibitors, Reversible
Atropinum, atropine

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