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Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication

Archives of Toxicology

May 1, 2000

T M Shih, John H McDonough

PMID: 10877003

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Abstract

The ability of the nerve agents tabun, sarin, soman, GF, VR, and VX to produce brain seizures and the effectiveness of the anticholinergics biperiden HCl or atropine SO4 as an anticonvulsant treatment were studied in a guinea-pig model. All animals were implanted a week prior to the exp...read more

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tabun
Polychemotherapy
Cholinesterase Inhibitors, Reversible
Anticholinergic Agents
Atropinum, atropine
Electroencephalogram
Lethal Dose 50
Organopyrophosphorus Compounds
Insecticides, Organothiophosphate, Antagonists
Adrenal Cortex
25
3
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Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication

Archives of Toxicology

May 1, 2000

T M Shih, John H McDonough

PMID: 10877003

DOI:

Abstract

The ability of the nerve agents tabun, sarin, soman, GF, VR, and VX to produce brain seizures and the effectiveness of the anticholinergics biperiden HCl or atropine SO4 as an anticonvulsant treatment were studied in a guinea-pig model. All animals were implanted a week prior to the exp...read more

Mentioned in this Paper

tabun
Polychemotherapy
Cholinesterase Inhibitors, Reversible
Anticholinergic Agents
Atropinum, atropine
25
3

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  • Citations35
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  • Citations35
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